Evidence map›Paper›PMID 38834745›Full record

ArticleBritish journal of cancer2024

CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas.

Lin Qi, Yuchen Du, Yulun Huang, Mari Kogiso, Huiyuan Zhang, Sophie Xiao, Aalaa Abdallah, Milagros Suarez, Long Niu, Zhi-Gang Liu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lin Qi *Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 510080, China.
Yuchen Du *Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Yulun Huang *Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-5297-6967
Mari KogisoTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Huiyuan ZhangTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Sophie XiaoProgram of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Aalaa AbdallahProgram of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Milagros SuarezProgram of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Long NiuProgram of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Zhi-Gang LiuTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-4043-3196
Holly LindsayTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Frank K BraunTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Clifford StephenCenter for Epigenetics & Disease Prevention, Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-0657-6484
Peter J DaviesCenter for Epigenetics & Disease Prevention, Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA.
Wan Yee TeoThe Laboratory of Pediatric Brain Tumor Research Office, SingHealth Duke-NUS Academic Medical Center, Singapore, 169856, Singapore.
Adesina AdenkunleDepartment of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Patricia BaxterTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Jack Mf SuTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Xiao-Nan LiProgram of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. xiaonan.li@northwestern.edu.ORCID http://orcid.org/0000-0002-6719-3789

Funding

Matching panels of in vivo and in vitro model system of pediatric brain tumorsU01CA217613 · NCI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI LI, XIAONAN · 2020 to 2024
$2.9M
(PQD-5) Patient derived orthotopic xenograft models for drug response predictionR01CA185402 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LI, XIAONAN · 2014 to 2017
$1.3M
National Natural Science Foundation of China (National Science Foundation of China) 32100563National Natural Science Foundation of China (National Science Foundation of China) 8217112078NCI NIH HHS R01 CA185402NCI NIH HHS U01 CA217613U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) CA185402
6 · The paper itself

Abstract

backgroundDiffuse invasion remains a primary cause of treatment failure in pediatric high-grade glioma (pHGG). Identifying cellular driver(s) of pHGG invasion is needed for anti-invasion therapies.

methodsTen highly invasive patient-derived orthotopic xenograft (PDOX) models of pHGG were subjected to isolation of matching pairs of invasive (HGG

resultspHGG

conclusionWe revealed significantly increased invasive capacities in HGG

Indexed as

AC133 AntigenBrain NeoplasmsCD57 AntigensGliomaNeoplasm InvasivenessNeoplastic Stem CellsAnimalsChildHumansMiceAC133 AntigenCD57 AntigensPROM1 protein, human

Identifiers

PMID38834745
PMCPMC11263392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.