Evidence map›Paper›PMID 38834651›Full record

ArticleScientific reports2024

Evaluation of antibacterial, cytotoxicity, and apoptosis activity of novel chromene-sulfonamide hybrids synthesized under solvent-free conditions and 3D-QSAR modeling studies.

Shakila Ghomashi, Reihane Ghomashi, Mohammad Sadegh Damavandi, Zeynab Fakhar, Seyedeh Yasaman Mousavi, Azhar Salari-Jazi, Sajjad Gharaghani, Ahmad Reza Massah

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Halogenated 3-Nitro-2Antibiotics (Basel, Switzerland) · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shakila GhomashiDepartment of Medicinal Chemistry, Shahreza Branch, Islamic Azad University, P.O. Box 311-86145, Shahreza, Isfahan, Iran.
Reihane GhomashiDepartment of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Sadegh DamavandiDepartment of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Zeynab FakharLaboratory of Bioinformatics and Drug Design (LBD), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Seyedeh Yasaman MousaviDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Azhar Salari-JaziFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland. azhar_sallari@yahoo.com.ORCID 0000-0001-6591-1815
Sajjad GharaghaniLaboratory of Bioinformatics and Drug Design (LBD), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. s.gharaghani@ut.ac.ir.ORCID 0000-0001-5468-4258
Ahmad Reza MassahDepartment of Chemistry, Shahreza Branch, Islamic Azad University, P.O. Box 311-86145, Shahreza, Isfahan, Iran. massah@iaush.ac.ir.ORCID 0000-0001-8843-3190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, eleven novel chromene sulfonamide hybrids were synthesized by a convenient method in accordance with green chemistry. At first, chromene derivatives (1-9a) were prepared through the multi-component reaction between aryl aldehydes, malononitrile, and 3-aminophenol. Then, synthesized chromenes were reacted with appropriate sulfonyl chlorides by grinding method to give the corresponding chromene sulfonamide hybrids (1-11b). Synthesized hybrids were obtained in good to high yield and characterized by IR,

Indexed as

Anti-Bacterial AgentsApoptosisBenzopyransMicrobial Sensitivity TestsMolecular Docking SimulationQuantitative Structure-Activity RelationshipSulfonamidesAnimalsCell LineMiceAnti-Bacterial AgentsBenzopyransSulfonamides3D-QSAR modeling studiesADMETAntibacterialApoptosis activityChromenesCytotoxicity activityDockingPharmacokineticsSolvent-free conditionsSulfonamidesSynthesis

Identifiers

PMID38834651
PMCPMC11150261

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.