Evidence map›Paper›PMID 38834593›Full record

ArticleScientific reports2024

Associations between HIV stigma and health-related quality-of-life among people living with HIV: cross-sectional analysis of data from HPTN 071 (PopART).

Emily Hall, Katherine Davis, Julius Ohrnberger, Michael Pickles, Simon Gregson, Ranjeeta Thomas, James R Hargreaves, Triantafyllos Pliakas, Justin Bwalya, Rory Dunbar and 12 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Emily HallMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Katherine DavisMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK. k.davis18@imperial.ac.uk.
Julius OhrnbergerMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Michael PicklesMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Simon GregsonMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Ranjeeta ThomasDepartment of Health Policy, London School of Economics, London, UK.
James R HargreavesDepartment of Public Health, Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Triantafyllos PliakasDepartment of Public Health, Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Justin BwalyaZambart, School of Medicine, University of Zambia, Lusaka, Zambia.
Rory DunbarDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health, University of Stellenbosch, Cape Town, South Africa.
Tila MaingaZambart, School of Medicine, University of Zambia, Lusaka, Zambia.
Kwame ShanaubeZambart, School of Medicine, University of Zambia, Lusaka, Zambia.
Graeme HoddinottDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health, University of Stellenbosch, Cape Town, South Africa.
Virginia BondZambart, School of Medicine, University of Zambia, Lusaka, Zambia.
Peter BockDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health, University of Stellenbosch, Cape Town, South Africa.
Helen AylesDepartment of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Anne L StanglHera Solutions, Baltimore, MD, USA.
Deborah DonnellVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Richard HayesDepartment of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Sarah FidlerDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Katharina HauckMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
HPTN 071 (PopART) study team

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Stellenbosch University Clinical Trial Unit, Cape Town, South AfricaUM1AI069521 · NIAID · STELLENBOSCH UNIVERSITY · PI Shaun Barnabas, Anneke Catharina Hesseling · 2012 to 2026
$21.5M
Medical Research Council MR/R010161/1Medical Research Council MR/X020258/1Medical Research Council (MRC) and the UK Foreign, Commonwealth & Development Office (FCDO) MR/R015600/1National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Modelling and Health Economics NIHR200908National Institute of Allergy and Infectious Diseases UM1-AI068613National Institute of Allergy and Infectious Diseases UM1-AI068617National Institute of Allergy and Infectious Diseases UM1-AI068619NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1 AI069521Wellcome TrustWellcome Trust 220098/Z/20/Z
6 · The paper itself

Abstract

People living with HIV (PLHIV) report lower health-related quality-of-life (HRQoL) than HIV-negative people. HIV stigma may contribute to this. We explored the association between HIV stigma and HRQoL among PLHIV. We used cross-sectional data from 3991 randomly selected PLHIV who were surveyed in 2017-2018 for HPTN 071 (PopART), a cluster randomised trial in Zambia and South Africa. Participants were 18-44 years, had laboratory-confirmed HIV infection, and knew their status. HRQoL was measured using the EuroQol-5-dimensions-5-levels (EQ-5D-5L) questionnaire. Stigma outcomes included: internalised stigma, stigma experienced in the community, and stigma experienced in healthcare settings. Associations were examined using logistic regression. Participants who had experienced community stigma (n = 693/3991) had higher odds of reporting problems in at least one HRQoL domain, compared to those who had not (adjusted odds ratio, aOR: 1.51, 95% confidence interval, 95% Cl: 1.16-1.98, p = 0.002). Having experienced internalised stigma was also associated with reporting problems in at least one HRQoL domain (n = 552/3991, aOR: 1.98, 95% CI: 1.54-2.54, p < 0.001). However, having experienced stigma in a healthcare setting was less common (n = 158/3991) and not associated with HRQoL (aOR: 1.04, 95% CI: 0.68-1.58, p = 0.850). A stronger focus on interventions for internalised stigma and stigma experienced in the community is required.

Indexed as

HIV InfectionsQuality of LifeSocial StigmaAdolescentAdultCross-Sectional StudiesFemaleHumansMaleSouth AfricaSurveys and QuestionnairesYoung AdultZambia

Identifiers

PMID38834593
PMCPMC11150264

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.