Evidence map›Paper›PMID 38834510›Full record

ReviewJournal of veterinary science2024

Current strategies using 3D organoids to establish

Islam Mohamed Saadeldin, Seif Ehab, Ahmed Elsayed Noreldin, Ayman Abdel-Aziz Swelum, Seonggyu Bang, Hyejin Kim, Ki Young Yoon, Sanghoon Lee, Jongki Cho

Abstract readReview
In one paragraph

Review in Journal of veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Modeling Post-Implantation Mammalian Embryogenesis Using AdvancedInternational journal of molecular sciences · 2026
    Review
  4. Review
  5. Review
  6. A simplified method for immunostaining single endometrial and liver organoids.Journal, genetic engineering & biotechnology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Islam Mohamed SaadeldinComparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID https://orcid.org/0000-0002-7633-730X
Seif EhabBiomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza 11341, Egypt.ORCID https://orcid.org/0000-0003-1906-4269
Ahmed Elsayed NoreldinDepartment of Histology and Cytology, Faculty of Veterinary Medicine, Damanhour University, the Scientific Campus, Damanhour 22511, Egypt.ORCID https://orcid.org/0000-0002-8344-0807
Ayman Abdel-Aziz SwelumDepartment of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0000-0003-3247-5898
Seonggyu BangCollege of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.ORCID https://orcid.org/0000-0002-2513-4887
Hyejin KimDivision in Biomedical Art, Department of Fine Art, Incheon Catholic University Graduate School, Incheon 21986, Korea.ORCID https://orcid.org/0000-0002-6846-574X
Ki Young YoonDepartment of Companion Animal, Shingu College, Seongnam 13174, Korea.ORCID https://orcid.org/0000-0003-4891-2247
Sanghoon LeeCollege of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.ORCID https://orcid.org/0000-0002-1265-3821
Jongki ChoCollege of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea. cjki@snu.ac.kr.ORCID https://orcid.org/0000-0002-8431-0457

Funding

Brain Pool Program 2021H1D3A2A02040098National Research Foundation of Korea 2021R1A2C2009294National Research Foundation of Korea 2022R1I1A1A01065412
6 · The paper itself

Abstract

importanceThe creation of robust maternal-embryonic interactions and implantation models is important for comprehending the early stages of embryonic development and reproductive disorders. Traditional two-dimensional (2D) cell culture systems often fail to accurately mimic the highly complex OBSERVATIONS: This review summarizes the current strategies and advancements in the field of 3D organoids to establish maternal-embryonic interaction and implantation models for use in research and personalized medicine in assisted reproductive technology. The concepts of endometrial organoids, menstrual blood flow organoids, placental trophoblast organoids, stem cell-derived blastoids, and in vitro-generated embryo models are discussed in detail. We show the incorportaion of organoid systems and microfluidic technology to enhance tissue performance and precise management of the cellular surroundings. CONCLUSIONS AND RELEVANCE: This review provides insights into the future direction of modeling maternal-embryonic interaction research and its combination with other powerful technologies to interfere with this dialogue either by promoting or hindering it for improving fertility or methods for contraception, respectively. The merging of organoid systems with microfluidics facilitates the creation of sophisticated and functional organoid models, enhancing insights into organ development, disease mechanisms, and personalized medical investigations.

Indexed as

OrganoidsAnimalsCell Culture Techniques, Three DimensionalEmbryo ImplantationFemaleHumansPregnancyembryonic structuresendometriummicrofluidicsOrganoidstissue engineering

Identifiers

PMID38834510
PMCPMC11156602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.