ArticleJournal of veterinary science2024
Histopathological evaluation of the lungs in experimental autoimmune encephalomyelitis.
Article in Journal of veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Role of Ethyl Acetate Fraction fromMolecules (Basel, Switzerland) · 2026Article
- Comparative lobe-specific histomorphometric evaluation of pulmonary architecture, fibrosis, and alveolar macrophage distribution in swine raised under different management systems.Veterinary world · 2026Article
- Elevated osteopontin reflects systemic inflammation in experimental autoimmune encephalomyelitis.Anatomy & cell biology · 2025Article
- A potential interference of chemoreception in inflamed vomeronasal organ with experimental autoimmune encephalomyelitis.Anatomy & cell biology · 2025Article
- Reproductive Dysfunction in Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis.Experimental neurobiology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
importanceExperimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis characterized by inflammation within the central nervous system. However, inflammation in non-neuronal tissues, including the lungs, has not been fully evaluated.
objectiveThis study evaluated the inflammatory response in lungs of EAE mice by immunohistochemistry and histochemistry.
methodsEight adult C57BL/6 mice were injected with myelin oligodendrocyte glycoprotein
resultsHistopathological examination revealed inflammatory lesions in the lungs of EAE mice, characterized by infiltration of myeloperoxidase (MPO)- and galectin-3-positive cells, as determined by immunohistochemistry. Increased numbers of collagen fibers in the lungs of EAE mice were confirmed by histopathological analysis. Western blotting revealed significantly elevated level of osteopontin (OPN), cluster of differentiation 44 (CD44), MPO and galectin-3 in the lungs of EAE mice compared with normal controls ( CONCLUSIONS AND RELEVANCE: Taken together, these findings suggest that the increased OPN level in lungs of EAE mice led to inflammation; concurrent increases in proinflammatory factors (OPN and galectin-3) caused pulmonary impairment.
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Registered trials
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