Evidence map›Paper›PMID 38834136›Full record

ArticleExperimental hematology2024

Dose-dependent effects of Dnmt3a in an inducible murine model of Kras

Jason H Rogers, Allison Rosen, Jaime M Reyes, Shamika Ketkar, Shannon E Conneely, Rohit Gupta, Luibin Yang, Matthew B Miller, Geraldo Medrano, Rogelio Aguilar and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jason H RogersDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX.
Allison RosenDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX.
Jaime M ReyesCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Shamika KetkarDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Shannon E ConneelyDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX.
Rohit GuptaDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Department of Medicine, Baylor College of Medicine, Houston, TX.
Luibin YangDepartment of Medicine, Baylor College of Medicine, Houston, TX.
Matthew B MillerDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Geraldo MedranoDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Rogelio AguilarDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Nneka UchendaDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Margaret A GoodellDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Rachel E RauDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Department of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children's Hospital, University of Washington, Seattle, WA.. Electronic address: Rachel.Rau@seattlechildrens.org.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAMK12CA090433 · NCI · BAYLOR COLLEGE OF MEDICINE · PI CARL E ALLEN, Donald W. Parsons · 2002 to 2026
$18.5M
DEFINING THE ROLE OF DOT1L IN DNMT3A-MUTANT LEUKEMIAK08CA201611 · NCI · BAYLOR COLLEGE OF MEDICINE · PI RAU, RACHEL E · 2017 to 2019
$486k
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS K08 CA201611NCI NIH HHS K12 CA090433NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574
6 · The paper itself

Abstract

DNMT3A mutations are frequently found in clonal hematopoiesis and a variety of hematologic malignancies, including acute myeloid leukemia. An assortment of mouse models have been engineered to explore the tumorigenic potential and malignant lineage bias due to loss of function of DNMT3A in consort with commonly comutated genes in myeloid malignancies, such as Flt3, Nras, Kras, and c-Kit. We employed several tamoxifen-inducible Cre-ER

Indexed as

DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AProto-Oncogene Proteins p21(ras)AnimalsDisease Models, AnimalLeukemia, Myeloid, AcuteMiceMice, KnockoutMice, TransgenicDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADnmt3a protein, mouseHras protein, mouseProto-Oncogene Proteins p21(ras)

Identifiers

PMID38834136
PMCPMC11288274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.