ArticleCurrent biology : CB2024
Prefrontal cortical ripples mediate top-down suppression of hippocampal reactivation during sleep memory consolidation.
Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
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- Neocortical pyramidal cells with axon-carrying basal dendrites: a prominent feature regulated by activity.Brain structure & function · 2026Article
- GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.Translational psychiatry · 2026Article
- Hippocampal synchrony dynamically gates cortical connectivity across brain states.Scientific reports · 2026Article
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- Closed-loop neuromodulation: a paradigm shift in precision neuroscience for clinical and cognitive applications.Frontiers in neuroscience · 2026Review
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation.bioRxiv : the preprint server for biology · 2025Article
- REM sleep prefrontal ripple chains mediate distinct cortical-hippocampal reactivation patterns compared to NREM ripples.bioRxiv : the preprint server for biology · 2025Article
- Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations.bioRxiv : the preprint server for biology · 2024Article
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Abstract
Consolidation of initially encoded hippocampal representations in the neocortex through reactivation is crucial for long-term memory formation and is facilitated by the coordination of hippocampal sharp-wave ripples (SWRs) with cortical slow and spindle oscillations during non-REM sleep. Recent evidence suggests that high-frequency cortical ripples can also coordinate with hippocampal SWRs in support of consolidation; however, the contribution of cortical ripples to reactivation remains unclear. We used high-density, continuous recordings in the hippocampus (area CA1) and prefrontal cortex (PFC) over the course of spatial learning and show that independent PFC ripples dissociated from SWRs are prevalent in NREM sleep and predominantly suppress hippocampal activity. PFC ripples paradoxically mediate top-down suppression of hippocampal reactivation rather than coordination, and this suppression is stronger for assemblies that are reactivated during coordinated CA1-PFC ripples for consolidation of recent experiences. Further, we show non-canonical, serial coordination of independent cortical ripples with slow and spindle oscillations, which are known signatures of memory consolidation. These results establish a role for prefrontal cortical ripples in top-down regulation of behaviorally relevant hippocampal representations during consolidation.
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