Evidence map›Paper›PMID 38833935›Full record

ArticlePsychiatry research2024

The role of recurrent trauma on post-traumatic stress disorder symptoms and substance use among trauma exposed youth.

John Leri, Josh M Cisler, Cody G Dodd, Shaunna L Clark, Leslie Taylor, Arrian Theodorou, Anissa Belford, Israel Liberzon, Paul J Rathouz, D Jeffrey Newport and 3 more

Abstract read
In one paragraph

Article in Psychiatry research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

John LeriDepartment of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Austin, TX 78712, United States. Electronic address: john.leri@austin.utexas.edu.
Josh M CislerDepartment of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Austin, TX 78712, United States.
Cody G DoddDepartment of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, United States.
Shaunna L ClarkDepartment of Psychiatry & Behavioral Sciences, Texas A&M University, United States.
Leslie TaylorFaillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, United States.
Arrian TheodorouThe University of North Texas Health Science Center, United States.
Anissa BelfordDepartment of Psychiatry and Behavioral Sciences, The University of Texas at San Antonio, United States.
Israel LiberzonDepartment of Psychiatry & Behavioral Sciences, Texas A&M University, United States.
Paul J RathouzDepartment of Population Health, The University of Texas at Austin Dell Medical School, United States.
D Jeffrey NewportDepartment of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Austin, TX 78712, United States; Department of Women's Health, The University of Texas at Austin Dell Medical School, United States.
Cecilia DevargasDepartment of Psychiatry, Texas Tech University Health Sciences Center El Paso, United States.
Karen WagnerDepartment of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, United States.
Charles B NemeroffDepartment of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Austin, TX 78712, United States.

Funding

Neurochemical & Behavioral Correlates of ETOH EffectsT32AA007471 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI Kimberly Nixon · 1987 to 2026
$9.2M
Advancing the Early Psychosis Intervention Network in Texas (EPINET-TX)R01MH120599 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI LOPEZ, MOLLY A. · 2020 to 2023
$5.5M
Prediction of Alcohol Use Disorder and PTSD After Trauma in AdolescentsR01AA029090 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI CHARLES B NEMEROFF · 2022 to 2026
$4.4M
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omicsR01MH117293 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI CHARLES B NEMEROFF · 2018 to 2026
$4.3M
A multicenter pragmatic randomized trial evaluating effectiveness and safety of outpatient Foley catheter for cervical ripening in nulliparous women: a Type 1 hybrid effectiveness-implementation studyR01HD109229 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI ALISON G CAHILL, LISA Danielle LEVINE · 2022 to 2026
$3.4M
Glucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiologyR01MH113574 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABELSON, JAMES L, LIBERZON, ISRAEL · 2018 to 2022
$3.3M
The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.R01HD104297 · NICHD · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA, CLARK, SHAUNNA L · 2021 to 2025
$2.9M
Alcohol, Approach-Avoidance, and Neurocircuitry Interactions in PTSDR01AA030740 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Joshua M Cisler, Elizabeth Thomas Cox Lippard · 2023 to 2026
$2.7M
Single cell transcriptomic study of alcohol useR01AA030116 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Karolina Anna Aberg, Shaunna L Clark · 2023 to 2026
$2.4M
Dopamine Enhancement of fear extinction learning in PTSDR33MH108753 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI CISLER, JOSHUA M · 2020 to 2022
$1.1M
Building Research Capacity for Implementation of Outcomes Research and Evidence-Based trauma care after Mass Violence, in Ukraine.D43TW012463 · FIC · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Israel Liberzon · 2023 to 2026
$983k
Dopamine Enhancement of fear extinction learning in PTSDR21MH108753 · NIMH · UNIV OF ARKANSAS FOR MED SCIS · PI CISLER, JOSHUA M · 2016 to 2017
$715k
FIC NIH HHS D43 TW012463NIAAA NIH HHS R01 AA029090NIAAA NIH HHS R01 AA030116NIAAA NIH HHS R01 AA030740NIAAA NIH HHS T32 AA007471NICHD NIH HHS R01 HD104297NICHD NIH HHS R01 HD109229NIMH NIH HHS R01 MH113574NIMH NIH HHS R01 MH117293NIMH NIH HHS R01 MH120599NIMH NIH HHS R21 MH108753NIMH NIH HHS R33 MH108753
6 · The paper itself

Abstract

Comorbidity between post-traumatic stress disorder (PTSD) and substance use disorder may be explained by a prospective trauma risk conferred by both conditions. The current study modeled concurrent and prospective associations of trauma, PTSD symptoms, and substance use (SU) behavior among trauma exposed youth (ages 8-20). Clinical interviews assessed trauma exposure, PTSD symptom severity, and SU behavior at baseline and at six- and 12-month follow up study visits (N = 2,069). Structural equation models assessed the associations of trauma, PTSD symptoms, and SU behavior. Lifetime trauma was associated with more severe PTSD symptoms and SU behaviors, whereas trauma exposure during the study was only associated with PTSD symptoms. PTSD symptom severity was prospectively associated with trauma exposure. PTSD symptom severity and SU behavior at follow-up study visits were prospectively associated. These results highlight the dynamic interplay between trauma, PTSD symptoms, and SU behavior during youth, a developmental period during which complex psychiatric presentations can have longstanding consequences for health.

Indexed as

Stress Disorders, Post-TraumaticSubstance-Related DisordersAdolescentAdultChildComorbidityFemaleFollow-Up StudiesHumansMaleProspective StudiesRecurrenceSeverity of Illness IndexYoung AdultAdolescenceChildhoodChildhood trauma research networkEmerging adulthoodPTSDStressSubstance useTexas child mental health care consortium

Identifiers

PMID38833935
PMCPMC11450678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.