Evidence map›Paper›PMID 38833618›Full record

Observational studyEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2024

Infectious mass debulking in lead-associated endocarditis with a percutaneous aspiration system.

Roland Heck, Leonard Pitts, Julius Kaemmel, Leonhard Wert, Volkmar Falk, Gerhard Hindricks, Christoph Starck

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07769320 (A Multicenter, International, Retrospective Observational Study Evaluating the Safety and Effectiveness of the AngioVac System Across Clinical Indications), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07769320 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Multicenter, International, Retrospective Observational Study Evaluating the Safety and Effectiveness of the AngioVac System Across Clinical Indications

TypeobservationalSponsorCharite University, Berlin, GermanyRan2026 to 2027Enrolled1,000ConditionsIntracardiac Thrombus, Intracardiac Mass, Intravascular Thrombosis, VegetationArmsRetrospective analysis of assigned treatment
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roland HeckDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, Berlin 13353, Germany.ORCID 0000-0001-7616-8780
Leonard PittsDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, Berlin 13353, Germany.ORCID 0009-0006-0339-5791
Julius KaemmelDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, Berlin 13353, Germany.ORCID 0000-0002-5640-0543
Leonhard WertDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, Berlin 13353, Germany.ORCID 0000-0002-2840-8724
Volkmar FalkDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, Berlin 13353, Germany.ORCID 0000-0002-7911-8620
Gerhard HindricksCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany.ORCID 0000-0002-0132-0773
Christoph StarckDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, Berlin 13353, Germany.ORCID 0000-0002-2753-1456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsDebulking of infective mass to reduce the burden if infective material is a fundamental principle in the surgical management of infection. The aim of this study was to investigate the validity of this principle in patients undergoing transvenous lead extraction in the context of bloodstream infection (BSI). METHODS AND

resultsWe performed an observational single-centre study on patients that underwent transvenous lead extraction due to a BSI, with or without lead-associated vegetations, in combination with a percutaneous aspiration system during the study period 2015-22. One hundred thirty-seven patients were included in the final analysis. In patients with an active BSI at the time of intervention, the use of a percutaneous aspiration system had a significant impact on survival (log-rank: P = 0.0082), while for patients with a suppressed BSI at the time of intervention, the use of a percutaneous aspiration system had no significant impact on survival (log-rank: P = 0.25).

conclusionA reduction of the infective burden by percutaneous debulking of lead vegetations might improve survival in patients with an active BSI.

Indexed as

Device RemovalProsthesis-Related InfectionsAgedAged, 80 and overDefibrillators, ImplantableEndocarditis, BacterialFemaleHumansMaleMiddle AgedPacemaker, ArtificialRetrospective StudiesRisk FactorsSuctionTime FactorsTreatment OutcomeAngioVacBloodstream infectionCardiac implantable electronic devicesCIEDEndocarditisTransvenous lead extraction

Identifiers

PMID38833618
PMCPMC11177155

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.