Evidence map›Paper›PMID 38833477›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance.

Na Wang, Biqing Zhu, Mary Alice Allnutt, Rosalie M Grijalva, Hongyu Zhao, Sreeganga S Chandra

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Na Wang *Department of Neurology, Yale University, New Haven, CT 06510.ORCID 0000-0001-9500-1142
Biqing Zhu *Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06510.ORCID 0000-0002-7428-6297
Mary Alice AllnuttDepartment of Neurology, Yale University, New Haven, CT 06510.
Rosalie M GrijalvaDepartment of Neuroscience, Yale University, New Haven, CT 06510.
Hongyu ZhaoProgram of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06510.ORCID 0000-0003-1195-9607
Sreeganga S ChandraDepartment of Neurology, Yale University, New Haven, CT 06510.ORCID 0000-0001-9035-1733

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NEUROBIOLOGY OF CORTICAL SYSTEMST32NS007224 · NINDS · YALE UNIVERSITY · PI CARDIN, JESSICA A · 1985 to 2025
$4.6M
Roles of the CSPalpha Chaperone Complex in Presynaptic Maintenance and ANCLR01NS083846 · NINDS · YALE UNIVERSITY · PI CHANDRA, SREEGANGA S · 2014 to 2018
$2.2M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
Investigating the Functions of RME8 in Parkinson's DiseaseR21NS132546 · NINDS · YALE UNIVERSITY · PI CHANDRA, SREEGANGA S · 2023 to 2024
$461k
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R01 NS083846HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R21NS132546HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 5T32NS007224-38NCATS NIH HHS UL1 TR001863NIH HHS S10 OD030363Nina Compagnon Hirshfield Parkinson's Disease Research Fund no numberNINDS NIH HHS R01 NS083846NINDS NIH HHS R21 NS132546NINDS NIH HHS T32 NS007224
6 · The paper itself

Abstract

Synapse maintenance is essential for generating functional circuitry, and decrement in this process is a hallmark of neurodegenerative disease. Yet, little is known about synapse maintenance in vivo. Cysteine string protein α (CSPα), encoded by the

Indexed as

HSP40 Heat-Shock ProteinsMembrane ProteinsMice, KnockoutNeuronsSynapsesTranscriptomeAnimalsMiceNeurogliacysteine string proteinHSP40 Heat-Shock ProteinsMembrane ProteinsautophagosomechaperoneNeurexin1–Neuroligin 1synapse loss

Identifiers

PMID38833477
PMCPMC11181078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.