ArticleSkeletal radiology2025
Assessment of bone marrow edema on dual-energy CT scans in people with diabetes mellitus and suspected Charcot neuro-osteoarthropathy.
Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Plantar Pressure and Radiographic Deformity at Diagnosis of Active Charcot Neuro-Osteoarthropathy as Potential Prognostic Markers for Time to Remission.Journal of clinical medicine · 2026Article
- MRI Distribution of Foot Bone Marrow Edema of Presumed Algodystrophic/BMES-Like Origin: A Small Retrospective Case Series with 3-Month Clinical Follow-Up.Journal of clinical medicine · 2026Article
- Burning Issues/Hot Topics: The Charcot Foot.Journal of clinical medicine · 2026Review
- Radiological Assessment of Charcot Neuro-Osteoarthropathy in Diabetic Foot: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis.Scientific reports · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveThis study aimed to quantitatively assess the diagnostic value of bone marrow edema (BME) detection on virtual non-calcium (VNCa) images calculated from dual-energy CT (DECT) in people with diabetes mellitus and suspected Charcot neuro-osteoarthropathy (CN). MATERIALS AND
methodsPeople with diabetes mellitus and suspected CN who underwent DECT of the feet (80kVp/Sn150kVp) were included retrospectively. Two blinded observers independently measured CT values on VNCa images using circular regions of interest in five locations in the midfoot (cuneiforms, cuboid and navicular) and the calcaneus of the contralateral or (if one foot was available) the ipsilateral foot. Two clinical groups were formed, one with active CN and one without active CN (no-CN), based on the clinical diagnosis.
resultsThirty-two people with diabetes mellitus and suspected CN were included. Eleven had clinically active CN. The mean CT value in the midfoot was significantly higher in the CN group (-55.6 ± 18.7 HU) compared to the no-CN group (-94.4 ± 23.5 HU; p < 0.001). In the CN group, the difference in CT value between the midfoot and calcaneus was statistically significant (p = 0.003); this was not the case in the no-CN group (p = 0.357). The overall observer agreement was good for the midfoot (ICC = 0.804) and moderate for the calcaneus (ICC = 0.712). Sensitivity was 100.0% and specificity was 71.4% using a cutoff value of -87.6 HU.
conclusionThe detection of BME on VNCa images has a potential value in people with diabetes mellitus and suspected active CN.
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