Evidence map›Paper›PMID 38833152›Full record

ArticleAnnals of nuclear medicine2024

Intra-operative lymphatic mapping and sentinel node biopsy in laryngeal carcinoma using radiotracer injection.

Pegah Sahafi, Amin Saber Tanha, Maryam Daghighi, Ehsan Khadivi, Kamran Khazaeni, Dabbagh Kakhki Vahid Reza, Ramin Sadeghi

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Article in Annals of nuclear medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Pegah SahafiNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amin Saber TanhaNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam DaghighiSinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Ehsan KhadiviSinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Kamran KhazaeniSinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Dabbagh Kakhki Vahid RezaNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Ramin SadeghiNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sadeghir@mums.ac.ir.ORCID http://orcid.org/0000-0002-1666-5440

Funding

Mashhad University of Medical Sciences 920275
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine the value of sentinel lymph node biopsy (SLNB) in the laryngeal SCC, using intra-operative peri-tumoral injection of Tc-99m-phytate.

methodsPatients with biopsy-proven squamous cell carcinoma of the larynx were included. On the day of surgery, after anesthesia induction, suspension laryngoscopy was performed to inject 74 MBq/0.4 ml Tc-99m-phytate in four aliquots into the sub-mucosal peri-tumoral location. After a 10-min wait, a portable gamma probe was used to locate sentinel nodes. Subsequently, all patients underwent laryngectomy and neck dissection. Both sentinel nodes and non-sentinel nodes were examined using hematoxylin and eosin (H&E) staining.

resultsTwenty-six patients with a diagnosis of laryngeal carcinoma were included in the study. The SLN detection rate was 65.4%, with a 100% detection rate in the supraglottic region and a 52.6% detection rate for glottis/transglottic patients. Permanent pathology results showed lymph node involvement in four patients, but only one patient had a negative result in the SLNB, resulting in an overall false negative rate of 25%. The sensitivity of the SLN technique was 75% overall, 100% in the supraglottic region, and 67% in the glottis/transglottic region.

conclusionThe accuracy and feasibility of SLNB may be related to the location of the tumors in the larynx. For supraglottic tumors, the technique seems to be feasible with a low false negative rate. For glottis/transglottic tumors, both the detection rate and false negative rate seem to be suboptimal. Further studies are needed to validate our results.

Indexed as

Laryngeal NeoplasmsSentinel Lymph Node BiopsyAdultAgedCarcinoma, Squamous CellFemaleHumansInjectionsIntraoperative PeriodMaleMiddle AgedOrganotechnetium CompoundsPhytic AcidRadioactive TracersOrganotechnetium CompoundsPhytic AcidRadioactive Tracerstechnetium phytateLaryngeal SCCLarynxNuclear medicineSentinel lymph nodeSquamous cell carcinoma

Identifiers

PMID38833152

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