Evidence map›Paper›PMID 38833127›Full record

ReviewOphthalmology and therapy2024

Advancements in Imaging and Therapeutic Options for Dry Age-Related Macular Degeneration and Geographic Atrophy.

Andrea Servillo, Riccardo Sacconi, Gloria Oldoni, Eugenio Barlocci, Beatrice Tombolini, Marco Battista, Federico Fantaguzzi, Federico Rissotto, Cecilia Mularoni, Mariacristina Parravano and 4 more

Abstract readReview
In one paragraph

Review in Ophthalmology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrea ServilloSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Riccardo SacconiSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Gloria OldoniSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Eugenio BarlocciSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Beatrice TomboliniSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Marco BattistaSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Federico FantaguzziSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Federico RissottoSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Cecilia MularoniSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Mariacristina ParravanoDepartment of Ophthalmology, IRCCS - Fondazione Bietti, Rome, Italy.
Ilaria ZucchiattiSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Lea QuerquesSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Francesco BandelloSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Giuseppe QuerquesSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy. querques.giuseppe@hsr.it.ORCID http://orcid.org/0000-0002-3292-9581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, with dry AMD (d-AMD) leading to geographic atrophy (GA) and significant visual impairment. Multimodal imaging plays a crucial role in d-AMD diagnosis and management, allowing for detailed classification of patient phenotypes and aiding in treatment planning and prognosis determination. Treatment approaches for d-AMD have recently witnessed profound change with the development of specific drugs targeting the complement cascade, with the first anticomplement agents recently approved for GA treatment. Additionally, emerging strategies such as gene therapy and laser treatments may offer potential benefits, though further research is needed to fully establish their efficacy. However, the lack of effective therapies capable of restoring damaged retinal cells remains a major challenge. In the future, genetic treatments aimed at preventing the progression of d-AMD may emerge as a powerful approach. Currently, however, their development is still in the early stages.

Indexed as

Age-related macular degenerationAnticomplement factor therapyGeographic atrophyMultimodal imaging

Identifiers

PMID38833127
PMCPMC11246354

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.