Evidence map›Paper›PMID 38833013›Full record

ArticleDiscover oncology2024

Deciphering the role of zinc homeostasis in the tumor microenvironment and prognosis of prostate cancer.

Tao Guo, Jian Wang, Xiangyu Meng, Ye Wang, Yihaoyun Lou, Jianglei Ma, Shuang Xu, Xiangyu Ni, Zongming Jia, Lichen Jin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tao Guo *Department of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jian Wang *Department of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xiangyu Meng *Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ye WangDepartment of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yihaoyun LouDepartment of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jianglei MaDepartment of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Shuang XuDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xiangyu NiDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zongming JiaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Lichen JinDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chengyu WangDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Qingyang ChenDepartment of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Peng LiDepartment of Urology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, China. 1793727251@qq.com.
Yuhua HuangDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China. sdfyy_hyh@163.com.
Shancheng RenDepartment of Urology, Changzheng Hospital, Naval Medical University, Shanghai, China. renshancheng@gmail.com.

Funding

Education Commission of Shanghai Municipality 2023ZKZD46National Natural Science Foundation of China 82125025Postgraduate Research & Practice innovation Program of Jiangsu Province SJCX22_0680Science and Technology Commission of Shanghai Municipality 18410750200Shanghai Shenkang Hospital Development Center SHDC12022117Top Talent Support Program for young and middle-aged people of Wuxi Health Committee HB2020041
6 · The paper itself

Abstract

backgroundDysregulation of zinc homeostasis is widely recognized as a hallmark feature of prostate cancer (PCa) based on the compelling clinical and experimental evidence. Nevertheless, the implications of zinc dyshomeostasis in PCa remains largely unexplored.

methodsIn this research, the zinc homeostasis pattern subtype (ZHPS) was constructed according to the profile of zinc homeostasis genes. The identified subtypes were assessed for their immune functions, mutational landscapes, biological peculiarities and drug susceptibility. Subsequently, we developed the optimal signature, known as the zinc homeostasis-related risk score (ZHRRS), using the approach won out in multifariously machine learning algorithms. Eventually, clinical specimens, Bayesian network inference and single-cell sequencing were used to excavate the underlying mechanisms of MT1A in PCa.

resultsThe zinc dyshomeostasis subgroup, ZHPS2, possessed a markedly worse prognosis than ZHPS1. Moreover, ZHPS2 demonstrated a more conspicuous genomic instability and better therapeutic responses to docetaxel and olaparib than ZHPS1. Compared with traditional clinicopathological characteristics and 35 published signatures, ZHRRS displayed a significantly improved accuracy in prognosis prediction. The diagnostic value of MT1A in PCa was substantiated through analysis of clinical samples. Additionally, we inferred and established the regulatory network of MT1A to elucidate its biological mechanisms.

conclusionsThe ZHPS classifier and ZHRRS model hold great potential as clinical applications for improving outcomes of PCa patients.

Indexed as

MT1APrognosisProstate cancerTumor microenvironmentZinc homeostasis

Identifiers

PMID38833013
PMCPMC11150232

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