Evidence map›Paper›PMID 38832982›Full record

Trial reportEuropean journal of applied physiology2024

Timing matters: diurnal variation of maximal fat oxidation and substrate oxidation rates in metabolic syndrome-a randomized crossover study.

Jabeur Methnani, Mohamed Mustapha Brahim, Aymen Elhraiech, Taieb Ach, Imed Latiri, Monia Zaouali, Sonia Rouatbi, Ali Bouslama, Jean-Fréderic Brun, Asma Omezzine and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jabeur MethnaniHigh Institute of Sport and Physical Education, University of Manouba, Ksar Said, Tunis, Tunisia. Jabeur.methnani@gmail.com.ORCID http://orcid.org/0000-0002-1422-3059
Mohamed Mustapha BrahimHigh Institute of Sport and Physical Education, University of Manouba, Ksar Said, Tunis, Tunisia.
Aymen ElhraiechService of Cardiology, University of Sousse, Sahloul University Hospital, Sousse, Tunisia.
Taieb AchLR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, 4002, Sousse, Tunisia.
Imed LatiriLR12SP09, Research Laboratory, Heart Failure, University of Sousse, Farhat HACHED University Hospital, Sousse, Tunisia.
Monia ZaoualiLR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, 4002, Sousse, Tunisia.
Sonia RouatbiLR12SP09, Research Laboratory, Heart Failure, University of Sousse, Farhat HACHED University Hospital, Sousse, Tunisia.
Ali BouslamaLR12SP11, Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia.
Jean-Fréderic BrunPHYMEDEXP, Université de Montpellier, CNRS, INSERM, CHU de Montpellier, 34295, Montpellier, France.
Asma Omezzine *LR12SP11, Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia.
Ezdine Bouhlel *High Institute of Sport and Physical Education, University of Manouba, Ksar Said, Tunis, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to investigate if diurnal oscillation in maximal fat oxidation (MFO) and substrate oxidation rates during exercise exists in subjects with metabolic syndrome (MetS).

methodsIn a randomized crossover design, 14 MetS patients were assigned to two graded exercise tests conditions performed in the morning (between 7:00 and 9:00 a.m) and in the afternoon (between 4:00 and 5:00 p.m). MFO was defined as the highest absolute value of fat oxidation obtained from the average of last 2-min stages during an indirect calorimetry test.

resultsMFO increased by 20.6% from morning to afternoon (p = 0.0002, Cohen's d = 0.52). There was a significant time of day, (p < 0.0001, η

conclusionOur study extends previous findings on the existence of diurnal variation in maximal fat oxidation to MetS patients, highlighting the afternoon as a more favorable time for fat utilization during exercise. These findings have practical implications for optimizing training timing in MetS patients. TRIAL REGISTRATION NUMBER: PACTR202306776991260.

Indexed as

Circadian RhythmCross-Over StudiesMetabolic SyndromeOxidation-ReductionAdultExerciseFemaleHumansLipid MetabolismMaleMiddle AgedCarbohydrates oxidationCircadian variationFATmaxLIPOXmaxSubstrates metabolism

Identifiers

PMID38832982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.