Evidence map›Paper›PMID 38832899›Full record

ArticleMicrobiology spectrum2024

Utilizing co-abundances of antimicrobial resistance genes to identify potential co-selection in the resistome.

Hannah-Marie Martiny, Patrick Munk, Christian Brinch, Frank M Aarestrup, M Luz Calle, Thomas N Petersen

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Soil management practices shape the abundance, diversity, and spread of antimicrobial resistance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Global Comparative Genomics ofLife (Basel, Switzerland) · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah-Marie MartinyResearch Group for Genomic Epidemiology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0001-6733-7888
Patrick MunkResearch Group for Genomic Epidemiology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0001-8813-4019
Christian BrinchResearch Group for Genomic Epidemiology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-5074-7183
Frank M AarestrupResearch Group for Genomic Epidemiology, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-7116-2723
M Luz CalleBiosciences Department, Faculty of Sciences and Technology, University of Vic - Central University of Catalonia, Vic, Spain.ORCID 0000-0001-9334-415X
Thomas N PetersenResearch Group for Genomic Epidemiology, Technical University of Denmark, Kongens Lyngby, Denmark.

Funding

EC | H2020 | H2020 Societal Challenges (SC) 874735Novo Nordisk Fonden (NNF) NNF16OC0021856
6 · The paper itself

Abstract

The rapid spread of antimicrobial resistance (AMR) is a threat to global health, and the nature of co-occurring antimicrobial resistance genes (ARGs) may cause collateral AMR effects once antimicrobial agents are used. Therefore, it is essential to identify which pairs of ARGs co-occur. Given the wealth of next-generation sequencing data available in public repositories, we have investigated the correlation between ARG abundances in a collection of 214,095 metagenomic data sets. Using more than 6.76∙10 IMPORTANCE: Understanding the collateral effects happening in a resistome can reveal previously unknown links between antimicrobial resistance genes (ARGs). Through the analysis of pairwise ARG abundances in 214K metagenomic samples, we observed that the co-abundance is highly dependent on the environmental context and argue that these correlations can be used to show the risk of co-selection occurring in different settings.

Indexed as

Anti-Bacterial AgentsBacteriaDrug Resistance, BacterialMetagenomicsAnimalsGenes, BacterialHigh-Throughput Nucleotide SequencingHumansMetagenomeSoil MicrobiologyAnti-Bacterial Agentsantimicrobial resistanceco-abundancescompositional data analysiscorrelationmetagenomicsmicrobiomenetwork analysis

Identifiers

PMID38832899
PMCPMC11218503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.