Evidence map›Paper›PMID 38832836›Full record

ArticleCritical care medicine2024

Beyond Unplanned ICU Transfers: Linking a Revised Definition of Deterioration to Patient Outcomes.

Thomas F Byrd, Tom A Phelan, Nicholas E Ingraham, Benjamin W Langworthy, Ajay Bhasin, Abhinab Kc, Genevieve B Melton-Meaux, Christopher J Tignanelli

Abstract read
In one paragraph

Article in Critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas F ByrdDivision of Hospital Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.
Tom A PhelanFairview Health Services, Minneapolis, MN.
Nicholas E IngrahamCenter for Learning Health System Sciences, University of Minnesota, Minneapolis, MN.
Benjamin W LangworthyDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN.
Ajay BhasinDivision of Hospital Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Abhinab KcUniversity of Minnesota Medical School, Minneapolis, MN.
Genevieve B Melton-MeauxCenter for Learning Health System Sciences, University of Minnesota, Minneapolis, MN.
Christopher J TignanelliCenter for Learning Health System Sciences, University of Minnesota, Minneapolis, MN.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Identifying Areas to Improve ICU Outcomes through Provider VariationK23HL166783 · NHLBI · UNIVERSITY OF MINNESOTA · PI Nicholas E Ingraham · 2023 to 2026
$645k
AHRQ HHS P30 HS029744NCATS NIH HHS UL1 TR002494NHLBI NIH HHS K23 HL166783
6 · The paper itself

Abstract

objectivesTo develop an electronic descriptor of clinical deterioration for hospitalized patients that predicts short-term mortality and identifies patient deterioration earlier than current standard definitions.

designA retrospective study using exploratory record review, quantitative analysis, and regression analyses.

settingTwelve-hospital community-academic health system. PATIENTS: All adult patients with an acute hospital encounter between January 1, 2018, and December 31, 2022.

interventionsNot applicable. MEASUREMENTS AND MAIN

resultsClinical trigger events were selected and used to create a revised electronic definition of deterioration, encompassing signals of respiratory failure, bleeding, and hypotension occurring in proximity to ICU transfer. Patients meeting the revised definition were 12.5 times more likely to die within 7 days (adjusted odds ratio 12.5; 95% CI, 8.9-17.4) and had a 95.3% longer length of stay (95% CI, 88.6-102.3%) compared with those who were transferred to the ICU or died regardless of meeting the revised definition. Among the 1812 patients who met the revised definition of deterioration before ICU transfer (52.4%), the median detection time was 157.0 min earlier (interquartile range 64.0-363.5 min).

conclusionsThe revised definition of deterioration establishes an electronic descriptor of clinical deterioration that is strongly associated with short-term mortality and length of stay and identifies deterioration over 2.5 hours earlier than ICU transfer. Incorporating the revised definition of deterioration into the training and validation of early warning system algorithms may enhance their timeliness and clinical accuracy.

Indexed as

Clinical DeteriorationCritical CareIntensive Care UnitsPatient TransferAdultAgedHumansMaleMiddle AgedRetrospective StudiesTreatment Outcome

Identifiers

PMID38832836
PMCPMC12724262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.