Evidence map›Paper›PMID 38832442›Full record

ReviewHistology and histopathology2025

Advances in 3D bioprinting to enhance translational applications in bone tissue engineering and regenerative medicine.

Miguel A Ortega, Diego De Leon-Oliva, Diego Liviu Boaru, Oscar Fraile-Martinez, Cielo García-Montero, Carlos Casanova, Natalio García-Honduvilla, Julia Bujan, Miguel A Saez, Melchor Álvarez-Mon and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Miguel A Ortega *Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Diego De Leon-Oliva *Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Diego Liviu BoaruDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Oscar Fraile-MartinezDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Cielo García-MonteroDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Carlos CasanovaDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Natalio García-HonduvillaDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Julia BujanDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Miguel A SaezDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Melchor Álvarez-MonDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Amador Velazquez De CastroDepartment of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, CI-BEREHD, University of Alcalá, Alcala de Henares, Spain.
Laura López-GonzálezRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.
Julio AceroRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.
Silvestra Barrena-BlázquezRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.
Raul DiazRamón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.

Funding

Mutua Madrileña, Programa de Actividades de I+D de la Comunidad de Madrid en Biomedicina P2022/BMD‑7321
6 · The paper itself

Abstract

Bone defects are due to trauma, infections, tumors, or aging, including bone fractures, bone metastases, osteoporosis, or osteoarthritis. The global burden of these demands research into innovative strategies that overcome the limitations of conventional autografts. In this sense, the development of three-dimensional (3D) bioprinting has emerged as a promising approach in the field of tissue engineering and regenerative medicine (TERM) for the on-demand generation and transplantation of tissues and organs, including bone. It combines biological materials and living cells, which are precisely positioned layer by layer. Despite obtaining some promising results, 3D bioprinting of bone tissue still faces several challenges, such as generating an effective vascular network to increase tissue viability. In this review, we aim to collect the main knowledge on methods and techniques of 3D bioprinting. Then, we will review the main biomaterials, their composition, and the rationale for their application in 3D bioprinting for the TERM of bone.

Indexed as

BioprintingBone and BonesPrinting, Three-DimensionalRegenerative MedicineTissue EngineeringAnimalsBiocompatible MaterialsBone RegenerationHumansTissue ScaffoldsTranslational Research, BiomedicalBiocompatible Materials

Identifiers

PMID38832442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.