Evidence map›Paper›PMID 38832003›Full record

ArticleJCEM case reports2024

Gut Microbiome Alterations Accompany Metabolic Normalization Following Bariatric Surgery in ROHHAD Syndrome.

Alessandra Granato, Paul M Ryan, Anthony Wong, Jill K Hamilton, Jayne S Danska

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JCEM case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alessandra GranatoGenetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 1H3, Canada.ORCID https://orcid.org/0009-0001-8761-5184
Paul M RyanDepartment of Paediatrics, University of Toronto, Toronto, ON, M5G 1X8, Canada.ORCID https://orcid.org/0000-0001-7251-6725
Anthony WongGenetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 1H3, Canada.ORCID https://orcid.org/0000-0001-6047-8944
Jill K HamiltonDepartment of Paediatrics, University of Toronto, Toronto, ON, M5G 1X8, Canada.ORCID https://orcid.org/0000-0002-1958-2800
Jayne S DanskaGenetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 1H3, Canada.ORCID https://orcid.org/0000-0002-6549-4991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid onset obesity with hypoventilation, hypothalamic, and autonomic dysregulation (ROHHAD) syndrome in childhood is characterized by abrupt onset weight gain and dysautonomia with variable neuroendocrine involvement. In the absence of definitive disease-modifying therapies, the primary management strategy remains symptom control. This case report describes the first successful correction of obesity, dysautonomia, and metabolic derangement in a patient with ROHHAD following Roux-en-Y gastric bypass. Anthropometrics, metabolic profiling, and stool microbiome composition were assessed in a longitudinal fashion. In the 48-month period following surgery, the patient body mass index (BMI) reduced by 9.5 kg/m

Indexed as

bariatric surgerygastroenterologymicrobiomeobesityROHHAD

Identifiers

PMID38832003
PMCPMC11146140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.