Evidence map›Paper›PMID 38831957›Full record

ArticleAdvances in redox research2021

Sympathoinhibition and Vasodilation Contribute to the Acute Hypotensive Response of the Superoxide Dismutase Mimic, MnTnBuOE-2-PyP

Sarah L Schlichte, Elizabeth J Pekas, Taylor J Bruett, Elizabeth A Kosmacek, Bryan T Hackfort, Jordan M Rasmussen, Kaushik P Patel, Song-Young Park, Rebecca E Oberley-Deegan, Matthew C Zimmerman

Abstract read
In one paragraph

Article in Advances in redox research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah L SchlichteDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE.
Elizabeth J PekasSchool of Health and Kinesiology, University of Nebraska Omaha, Omaha, NE.
Taylor J BruettDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE.
Elizabeth A KosmacekDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE.
Bryan T HackfortDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE.
Jordan M RasmussenDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE.
Kaushik P PatelDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE.
Song-Young ParkSchool of Health and Kinesiology, University of Nebraska Omaha, Omaha, NE.
Rebecca E Oberley-DeeganDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE.
Matthew C ZimmermanDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE.

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MIKULS, TED RICHARD · 2016 to 2025
$42.8M
The Role of Excitatory Input into the PVN on Increased Sympathetic Drive in HeartP01HL062222 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CORNISH, KURTIS G · 1999 to 2019
$32.2M
Visual control of locomotion in people with Parkinsons diseaseP20GM109090 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI STERGIOU, NIKOLAOS · 2014 to 2023
$20.5M
Nebraska Center for Nanomedicine- Pilot ProjectsP30GM127200 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2018 to 2022
$5.7M
Redox Biology CenterP30GM103335 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F · 2012 to 2016
$4.3M
Novel Target Mechanism (Renal Denervation) to Reduce Sodium Retention in Chronic Heart FailureR01DK114663 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PATEL, KAUSHIK P, ZHENG, HONG · 2017 to 2021
$2.1M
MnTE-2-PyP as a radioprotector in prostate cancer therapyR01CA178888 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OBERLEY-DEEGAN, REBECCA E · 2014 to 2018
$1.6M
Anti-Hypertensive Properties of the Antioxidant, MnTnBuOE-2-PyP5+, and its NanoformulationF31HL152580 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SCHLICHTE, SARAH L · 2021 to 2021
$19k
NCI NIH HHS R01 CA178888NHLBI NIH HHS F31 HL152580NHLBI NIH HHS P01 HL062222NIDDK NIH HHS R01 DK114663NIGMS NIH HHS P20 GM109090NIGMS NIH HHS P30 GM103335NIGMS NIH HHS P30 GM127200NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

The pathogenesis of hypertension has been linked to excessive levels of reactive oxygen species (ROS), particularly superoxide (O

Indexed as

HypertensionMnTnBuOE-2-PyP5+Superoxide DismutaseSympathetic Nerve ActivityVasodilation

Identifiers

PMID38831957
PMCPMC11146686

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.