Evidence map›Paper›PMID 38831627›Full record

Trial reportJournal of cosmetic dermatology2024

A two-center randomized controlled trial of a repairing mask as an adjunctive treatment for mild to moderate rosacea.

Liwei Wang, Yiyi Zhang, Lihong Chen, Dengfeng Yuan, Xiamei Feng, Jie Zheng, Xia Li, Chao Yuan

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Journal of cosmetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Integrated smart farm system forFrontiers in plant science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liwei WangSkin and Cosmetics Research Laboratory, Skin Disease Hospital of Tongji University, Shanghai, China.
Yiyi ZhangSkin and Cosmetics Research Laboratory, Skin Disease Hospital of Tongji University, Shanghai, China.
Lihong ChenDepartment of Dermatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dengfeng YuanShanghai Jahwa United Co., LTD, Shanghai, China.
Xiamei FengShanghai Jahwa United Co., LTD, Shanghai, China.
Jie ZhengDepartment of Dermatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xia LiDepartment of Dermatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chao YuanSkin and Cosmetics Research Laboratory, Skin Disease Hospital of Tongji University, Shanghai, China.

Funding

Clinical Research Special Project in the Health Industry of Shanghai Municipal Health Commission 20214Y0338Shanghai Science and Technology Development Foundation 16411961400Shanghai Skin Disease Hospital Dedicated Fund LCFY2020 07
6 · The paper itself

Abstract

objectiveTo investigate the efficacy and safety of a repairing mask as an adjunctive treatment for skin barrier maintenance of mild to moderate rosacea.

methodsPatients with rosacea were recruited in this dual center randomized controlled trial from November 2019 to December 2021. A total of 64 patients were included and randomized into two groups at a ratio of 3:1 into a mask group (n = 47) and a control group (n = 17). Patients in the mask group received treatment with Dr. Yu Centella asiatica repairing facial mask three times weekly for a duration of 6 weeks. All participants were instructed to continue their regimen of 50 mg oral minocycline twice daily and to apply Dr. Yu Intensive Hydrating Soft Cream twice daily. The primary endpoint of this study was the Investigator Global Assessment (IGA) score.

resultsA total of 54 patients completed this trial, with 41 in the mask group and 13 in the control group. After using this facial mask for 3 and 6 weeks, the IGA, facial skin dryness, facial flushing, and severity of skin lesion in the mask group showed significantly improvement (p < 0.05). Moreover, the change in the delta degree of skin flushing was significantly higher than that in the control group (p = 0.037). Throughout the study, no adverse events were reported in either group of participants.

conclusionThe Dr. Yu Centella asiatica repairing facial mask, as an adjunctive treatment of rosacea, appears to effectively repair and protect the skin barrier, alleviate cutaneous symptoms of rosacea, and is both efficacious and safe for patient use.

Indexed as

Plant ExtractsRosaceaSeverity of Illness IndexAdministration, CutaneousAdultCentellaCombined Modality TherapyFacial DermatosesFemaleHumansMaleMiddle AgedPhytotherapyTreatment OutcomeTriterpenesCentella asiatica extractPlant ExtractsTriterpenesadjuvant therapyminocyclinerepairing facial maskrosaceaskin barrier

Identifiers

PMID38831627
PMCPMC13648924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.