Evidence map›Paper›PMID 38831516›Full record

Trial reportThe British journal of nutrition2024

Legume-supplemented feed for children hospitalised with severe malnutrition: a phase II trial.

Kevin Walsh, Akglinta Kiosa, Peter Olupot-Olupot, Florence Alaroker, William Okiror, Margaret Nakuya, Tonny Tssenyondo, Denis Aromut, Bernard Charles Okalebo, Rita Muhindo and 4 more

Abstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kevin Walsh *Division of Diabetes, Endocrinology and Metabolism, Imperial College, 6th Floor Commonwealth Building, Hammersmith Campus, DuCane Road, LondonW12, UK.
Akglinta Kiosa *Division of Diabetes, Endocrinology and Metabolism, Imperial College, 6th Floor Commonwealth Building, Hammersmith Campus, DuCane Road, LondonW12, UK.
Peter Olupot-OlupotMbale Clinical Research Institute, Busitema University Faculty of Health Sciences, Mbale Campus, Palissa Road, PO Box 1966, Mbale, Uganda.
Florence AlarokerSoroti Regional Referral Hospital, Hospital Road, PO Box 289, Soroti, Uganda.
William OkirorMbale Clinical Research Institute, Busitema University Faculty of Health Sciences, Mbale Campus, Palissa Road, PO Box 1966, Mbale, Uganda.
Margaret NakuyaSoroti Regional Referral Hospital, Hospital Road, PO Box 289, Soroti, Uganda.
Tonny TssenyondoMbale Clinical Research Institute, Busitema University Faculty of Health Sciences, Mbale Campus, Palissa Road, PO Box 1966, Mbale, Uganda.
Denis AromutSoroti Regional Referral Hospital, Hospital Road, PO Box 289, Soroti, Uganda.
Bernard Charles OkaleboMbale Clinical Research Institute, Busitema University Faculty of Health Sciences, Mbale Campus, Palissa Road, PO Box 1966, Mbale, Uganda.
Rita MuhindoMbale Clinical Research Institute, Busitema University Faculty of Health Sciences, Mbale Campus, Palissa Road, PO Box 1966, Mbale, Uganda.
Ayub MpoyaKenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya.
Elizabeth C George *Medical Research Council Clinical Trials Unit (MRC CTU) at University College London, London, UK.
Gary S Frost *Division of Diabetes, Endocrinology and Metabolism, Imperial College, 6th Floor Commonwealth Building, Hammersmith Campus, DuCane Road, LondonW12, UK.ORCID 0000-0003-0529-6325
Kathryn Maitland *Mbale Clinical Research Institute, Busitema University Faculty of Health Sciences, Mbale Campus, Palissa Road, PO Box 1966, Mbale, Uganda.ORCID 0000-0002-0007-0645

Funding

Medical Research Council MC_UU_00004/05Wellcome Trust 203077
6 · The paper itself

Abstract

Children hospitalised with severe malnutrition have high mortality and readmission rates post-discharge. Current milk-based formulations target restoring ponderal growth but not the modification of gut barrier integrity or microbiome which increases the risk of gram-negative sepsis and poor outcomes. We propose that legume-based feeds rich in fermentable carbohydrates will promote better gut health and improve overall outcomes. We conducted an open-label phase II trial at Mbale and Soroti Regional Referral Hospitals, Uganda, involving 160 children aged 6 months to 5 years with severe malnutrition (mid-upper arm circumference (MUAC) < 11·5 cm and/or nutritional oedema). Children were randomised to a lactose-free, chickpea-enriched legume paste feed (LF) (

Indexed as

FabaceaeChild Nutrition DisordersChild, PreschoolDiarrheaDietary SupplementsFemaleHospitalizationHumansInfantMaleMalnutritionUgandaWeight GainAfrican childrenClinical trialLegume-based feedsSevere malnutrition

Identifiers

PMID38831516
PMCPMC7616506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.