Evidence map›Paper›PMID 38831451›Full record

ArticleCell communication and signaling : CCS2024

Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis.

Jiani Shen, Feng Li, Xu Han, Dongying Fu, Yiping Xu, Changjian Zhu, Zhou Liang, Ziwen Tang, Ruilin Zheng, Xinrong Hu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jiani Shen *Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Feng Li *Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xu Han *Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Dongying Fu *Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yiping XuDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Changjian ZhuDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhou LiangDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ziwen TangDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ruilin ZhengDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xinrong HuDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ruoni LinDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Qiaoqiao PeiDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jing NieDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Ning LuoDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiaoyan LiDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wei ChenDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Haiping MaoDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. maohp@mail.sysu.edu.cn.
Yi ZhouDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. zhouyi39@mail.sysu.edu.cn.
Xueqing YuDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. yuxq@mail.sysu.edu.cn.

Funding

Guangdong-Hong Kong-Macao-Joint Labs Program from Guangdong Science and Technology 2019B121205005Guangdong Special Support Program 2017TQ04R549National Natural Science Foundation of China 82270716National Natural Science Foundation of China 82270764Natural Science Foundation of Guangdong Province 2017A030306013NHC Key Laboratory of Clinical Nephrology (Sun Yat-Sen University) and Guangdong Provincial Key Laboratory of Nephrology 2020B1212060028
6 · The paper itself

Abstract

Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly elevated GSDMD in human and mouse LN kidneys, predominantly in CD11b

Indexed as

CalciumLupus NephritisPhosphate-Binding ProteinsAnimalsCell DifferentiationExtracellular TrapsFemaleGasderminsGranulocytesHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMyeloid CellsNeutrophilsCalciumGasderminsGSDMD protein, humanGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsCalcium influxGasdermin DGranulopoiesisLupus nephritisMyeloid cell

Identifiers

PMID38831451
PMCPMC11149269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.