Evidence map›Paper›PMID 38831438›Full record

ArticleBMC musculoskeletal disorders2024

Causal impact of DNA methylation on refracture in elderly individuals with osteoporosis - a prospective cohort study.

Bingtao Wen, Yaning Zhang, Jianhua He, Lei Tan, Guanggui Xiao, Zunliang Wang, Wei Cui, Bingxuan Wu, Xianhai Wang, Lei He and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bingtao WenDepartment of Orthopedics, Peking University International Hospital, Beijing, China.
Yaning ZhangCAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
Jianhua HeDepartment of Orthopedics, Peking University International Hospital, Beijing, China.
Lei TanDepartment of Orthopedics, Peking University International Hospital, Beijing, China.
Guanggui XiaoDepartment of Rehabilitation, the Second Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.
Zunliang WangBeijing University of Posts and Telecommunications, Beijing, China.
Wei CuiDepartment of Orthopedics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Bingxuan WuDepartment of Orthopedics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xianhai WangDepartment of Orthopedics, Changping District Hospital, Beijing, China.
Lei HeDepartment of Orthopedics, Changping District Hospital, Beijing, China.
Ming LiDepartment of Orthopedics, Tengzhou Central People's Hospital, Tengzhou, Shandong, China.
Zhongjiao ZhuDepartment of Orthopedics, Tengzhou Central People's Hospital, Tengzhou, Shandong, China.
Dacheng SangDepartment of Orthopaedic Surgery, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wannan Medical College, Wuhu, Anhui, China.
Changqing ZengCAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
Peilin JiaCAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
Fan LiuCAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
Tianzi LiuCAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China. tzliu@sinh.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoporotic vertebral compression fractures (OVCF) in the elderly increase refracture risk post-surgery, leading to higher mortality rates. Genome-wide association studies (GWAS) have identified susceptibility genes for osteoporosis, but the phenotypic variance explained by these genes has been limited, indicating the need to explore additional causal factors. Epigenetic modifications, such as DNA methylation, may influence osteoporosis and refracture risk. However, prospective cohorts for assessing epigenetic alterations in Chinese elderly patients are lacking. Here, we propose to conduct a prospective cohort study to investigate the causal network of DNA polymorphisms, DNA methylation, and environmental factors on the development of osteoporosis and the risk of refracture.

methodsWe will collect vertebral and peripheral blood from 500 elderly OVCF patients undergoing surgery, extract DNA, and generate whole genome genotype data and DNA methylation data. Observation indicators will be collected and combined with one-year follow-up data. A healthy control group will be selected from a natural population cohort. Epigenome-wide association studies (EWAS) of osteoporosis and bone mineral density will be conducted. Differential methylation analysis will compare candidate gene methylation patterns in patients with and without refracture. Multi-omics prediction models using genetic variants and DNA methylation sites will be built to predict OVCF risk. DISCUSSION: This study will be the first large-scale population-based study of osteoporosis and bone mineral density phenotypes based on genome-wide data, multi-time point methylation data, and phenotype data. By analyzing methylation changes related to osteoporosis and bone mineral density in OVCF patients, the study will explore the feasibility of DNA methylation in evaluating postoperative osteoporosis intervention effects. The findings may identify new molecular markers for effective anti-osteoporosis treatment and inform individualized prevention and treatment strategies.

trial registrationchictr.org.cn ChiCTR2200065316, 02/11/2022.

Indexed as

DNA MethylationOsteoporosisOsteoporotic FracturesSpinal FracturesAgedAged, 80 and overBone DensityChinaEpigenesis, GeneticFemaleFractures, CompressionGenome-Wide Association StudyHumansMaleMiddle AgedProspective StudiesDNA methylationOsteoporosisRefractureVertebral augmentationVertebral compression fracture

Identifiers

PMID38831438
PMCPMC11149363

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.