Evidence map›Paper›PMID 38831378›Full record

ArticleJournal of nanobiotechnology2024

Differential reinforcement of cGAS-STING pathway-involved immunotherapy by biomineralized bacterial outer membrane-sensitized EBRT and RNT.

Mengling Shen, Li Guo, Hengyu Zhang, Bingshu Zheng, Xinpei Liu, Jingyu Gu, Tao Yang, Chunfeng Sun, Xuan Yi

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengling ShenSchool of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, 226001, Jiangsu, China.
Li GuoSchool of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, 226001, Jiangsu, China.
Hengyu ZhangSchool of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, 226001, Jiangsu, China.
Bingshu ZhengDepartment of Nuclear Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Xinpei LiuSchool of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, 226001, Jiangsu, China.
Jingyu GuSchool of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, 226001, Jiangsu, China.
Tao YangDepartment of Radiotherapy, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Chunfeng SunDepartment of Nuclear Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China. sunchunfeng-nt@ntu.edu.cn.
Xuan YiSchool of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong, 226001, Jiangsu, China. xuanyi@ntu.edu.cn.

Funding

Postgraduate Research & Practice Innovation Program of Jiangsu Province SJCX23_1808the National Natural Science Foundation of China U2032134
6 · The paper itself

Abstract

Radiotherapy (RT), including external beam radiation therapy (EBRT) and radionuclide therapy (RNT), realizes physical killing of local tumors and activates systemic anti-tumor immunity. However, these effects need to be further strengthened and the difference between EBRT and RNT should be discovered. Herein, bacterial outer membrane (OM) was biomineralized with manganese oxide (MnO

Indexed as

Bacterial Outer MembraneImmunotherapyManganese CompoundsMembrane ProteinsNucleotidyltransferasesOxidesAnimalsBiomineralizationCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansHydrogen PeroxideImmunity, InnateImmunogenic Cell DeathMiceNanoparticlescGAS protein, humancGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHydrogen PeroxideManganese Compoundsmanganese oxideMembrane ProteinsNucleotidyltransferasesOxidesSTING1 protein, humanSting1 protein, mouseSTING ProteinBacterial outer membranecGAS-STING pathwayHypoxiaImmunotherapyRadiotherapy

Identifiers

PMID38831378
PMCPMC11145800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.