Evidence map›Paper›PMID 38831377›Full record

ArticleAlcohol, clinical & experimental research2024

Correspondence between the alcohol-P3 event-related potential and alcohol reward phenotypes among young adults.

Samuel F Acuff, Roberto U Cofresí, Austin Varner, Ashley A Dennhardt, Jeffrey J Sable, Bruce D Bartholow, James MacKillop, James G Murphy

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Article in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Samuel F AcuffDepartment of Psychology, The University of Memphis, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-1934-2639
Roberto U CofresíDepartment of Psychological Sciences, University of Missouri, Columbia, Missouri, USA.ORCID https://orcid.org/0000-0003-1131-6142
Austin VarnerDepartment of Psychology, The University of Memphis, Memphis, Tennessee, USA.ORCID https://orcid.org/0009-0002-1862-9459
Ashley A DennhardtDepartment of Psychology, The University of Memphis, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0001-6332-6575
Jeffrey J SableDepartment of Psychology, The University of Memphis, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-2378-5213
Bruce D BartholowDepartment of Psychological Sciences, University of Missouri, Columbia, Missouri, USA.ORCID https://orcid.org/0000-0002-9234-6417
James MacKillopPeter Boris Centre for Addiction Research, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-8695-1071
James G MurphyDepartment of Psychology, The University of Memphis, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0001-9378-8754

Funding

Supplement to Promote Diversity: Characterizing Low Alcohol Sensitivity in Laboratory and Real-World ContextsR01AA025451 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI BARTHOLOW, BRUCE D, PIASECKI, THOMAS M · 2018 to 2022
$2.7M
The role of religiosity, socioeconomic status and the relationship between behavioral economic variables as mediators of negative alcohol-related consequences in African American emerging adultsR01AA024930 · NIAAA · UNIVERSITY OF MEMPHIS · PI MACKILLOP, JAMES, MURPHY, JAMES G. · 2017 to 2021
$1.6M
Behavioral Economic Trajectories of Alcohol Misuse in Emerging Adults: Neuroeconomic Augmentation via ElectroencephalographyR21AA027679 · NIAAA · UNIVERSITY OF MEMPHIS · PI MACKILLOP, JAMES, MURPHY, JAMES G. · 2020 to 2021
$374k
A translational human laboratory Pavlovian conditioning model of individual differences in risk for alcohol cue incentive salience sensitization and longitudinal assessment of problematic alcohol useK99AA029169 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI COFRESI, ROBERTO U · 2022 to 2023
$329k
Integration of Electrophysiological and Behavioral Economic Models of Reward Among Heavy Drinking Emerging AdultsF31AA027140 · NIAAA · UNIVERSITY OF MEMPHIS · PI ACUFF, SAMUEL FISHER · 2019 to 2021
$109k
NIAAA NIH HHS F31 AA027140NIAAA NIH HHS K99 AA029169NIAAA NIH HHS R01 AA024930NIAAA NIH HHS R01 AA025451NIAAA NIH HHS R21 AA027679
6 · The paper itself

Abstract

backgroundBehavioral economic theory suggests that the value of alcohol depends upon elements of the choice context, such that increasing constraints on alternatives (e.g., price) or increasing the benefits of alcohol (e.g., social context) may result in greater likelihood of heavy drinking. The P3 event-related potential elicited by alcohol-related cues, a proposed marker of incentive salience, may be an electrophysiological parallel for behavioral economic alcohol demand. However, these indices have not been connected in prior research, and studies typically do not disaggregate social influences in the context of alcohol cue reactivity.

methodThe current study recruited heavy drinking young adults (N = 81) who completed measures of alcohol use and alcohol demand, in addition to a 2 (social/nonsocial) × 2 (alcohol/nonalcohol) visual oddball task to elicit the P3.

resultsIn multilevel models controlling for demographic characteristics, P3 reactivity was greater to alcohol (p < 0.001) and social (p < 0.001) cues than to nonalcohol and nonsocial cues, but without a significant interaction. Higher alcohol consumption (p = 0.02) and lower elasticity of demand (p = 0.01) were associated with greater P3 response to alcohol than nonalcohol cues.

conclusionsThe results highlight a brain-behavior connection that may be an important marker for alcohol reward across units of analysis and may be sensitive to changes in the economic choice contexts that influence the likelihood of alcohol use.

Indexed as

alcohol demandbehavioral economicscue reactivityelectroencephalographysocial

Identifiers

PMID38831377
PMCPMC12848482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.