Evidence map›Paper›PMID 38831324›Full record

ArticleBMC veterinary research2024

Evaluation the kill rate and mutant selection window of danofloxacin against Actinobacillus pleuropneumoniae in a peristaltic pump model.

Hongjuan Wang, Chengshui Liao, Ke Ding, Longfei Zhang, Lei Wang

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Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hongjuan WangCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Chengshui LiaoCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Ke DingCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Longfei ZhangCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, China. 1216591415@qq.com.
Lei WangCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, China. wlei_007@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundActinobacillus pleuropneumoniae is a serious pathogen in pigs. The abundant application of antibiotics has resulted in the gradual emergence of drugresistant bacteria, which has seriously affected treatment of disease. To aid measures to prevent the emergence and spread of drug-resistant bacteria, herein, the kill rate and mutant selection window (MSW) of danofloxacin (DAN) against A. pleuropneumoniae were evaluated.

methodsFor the kill rate study, the minimum inhibitory concentration (MIC) was tested using the micro dilution broth method and time-killing curves of DAN against A. pleuropneumoniae grown in tryptic soy broth (TSB) at a series drug concentrations (from 0 to 64 MIC) were constructed. The relationships between the kill rate and drug concentrations were analyzed using a Sigmoid E

resultsIn kill rate study, the MIC of DAN against A. pleuropneumoniae was 0.016 µg/mL. According to the kill rate, DAN exhibited concentration-dependent antibacterial activity against A. pleuropneumoniae. A bactericidal effect was observed when the DAN concentration reached 4-8 MIC. The kill rate increased constantly with the increase in DAN concentration, with a maximum value of 3.23 Log

conclusionThese kill rate and MSW results will provide valuable guidance for the use of DAN to treat A. pleuropneumoniae infections.

Indexed as

Actinobacillus InfectionsActinobacillus pleuropneumoniaeAnti-Bacterial AgentsFluoroquinolonesMicrobial Sensitivity TestsAnimalsDrug Resistance, BacterialMutationSwineSwine DiseasesAnti-Bacterial AgentsdanofloxacinFluoroquinolonesActinobacillus pleuropneumoniaeKill rateMutation selection windowPeristaltic pump modelPK/PD integration

Identifiers

PMID38831324
PMCPMC11145865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.