Evidence map›Paper›PMID 38831184›Full record

ArticleGeroScience2024

Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy.

Huanhuan Liu, Trent Davis, Silvana Duran-Ortiz, Tom Martino, Austin Erdely, Shane Profio, Benjamin Osipov, Gabriela G Loots, Darlene E Berryman, Patrick M O'Connor and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Huanhuan Liu *Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Trent Davis *Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Silvana Duran-OrtizOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Tom MartinoOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Austin ErdelyOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Shane ProfioOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Benjamin OsipovDepartment of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA.
Gabriela G LootsDepartment of Orthopaedic Surgery, University of California Davis Health, Sacramento, California, USA.
Darlene E BerrymanOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Patrick M O'ConnorOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
John J KopchickOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA. kopchick@ohio.edu.
Shouan ZhuOhio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA. zhus1@ohio.edu.ORCID 0000-0002-4973-1504

Funding

Modulating Growth Hormone Action as a Target for Improved Health and LongevityR01AG059779 · NIA · OHIO UNIVERSITY ATHENS · PI John Joseph Kopchick · 2018 to 2026
$4.7M
Growth hormone regulating chondrocyte metabolism for osteoarthritis developmentR01AR081804 · NIAMS · OHIO UNIVERSITY ATHENS · PI Shouan Zhu · 2023 to 2026
$2.0M
Defining the unique capacity of the miniature joint model for investigating the role of adipose tissue and its impacts on osteoarthritisR01AR082386 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bruce A. Bunnell, STUART B GOODMAN · 2024 to 2026
$1.9M
Obesity promoting protein malonylation and chondrocyte metabolic dysfunction in osteoarthritis developmentR15AR080813 · NIAMS · OHIO UNIVERSITY ATHENS · PI ZHU, SHOUAN · 2022 to 2022
$453k
Hevolution Foundation HF-AGE-008NIAMS NIH HHS R01 AR081804NIAMS NIH HHS R01 AR082386NIAMS NIH HHS R01AR082386NIAMS NIH HHS R15 AR080813NIAMS NIH HHS R15AR080813NIA NIH HHS R01 AG059779NIA NIH HHS R01AG059779Ohio University medical student seed grantRheumatology Research Foundation Innovative Research Award
6 · The paper itself

Abstract

Excessive growth hormone (GH) has been shown to promote joint degeneration in both preclinical and clinical studies. Little is known about the effect of disrupted GH or GH receptor (GHR) on joint health. The goal of this study is to investigate joint pathology in mice with either germline (GHR

Indexed as

ChondrocytesHypertrophyReceptors, SomatotropinAnimalsCartilage, ArticularDisease Models, AnimalFemaleMaleMiceMice, KnockoutOsteoarthritisOsteoarthritis, KneeX-Ray MicrotomographyReceptors, SomatotropinChondrocyteGrowth hormone receptorHypertrophyOsteoarthritis

Identifiers

PMID38831184
PMCPMC11336010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.