ReviewNature reviews. Molecular cell biology2024
SenNet recommendations for detecting senescent cells in different tissues.
Abstract readReview
In one paragraph
Review in Nature reviews. Molecular cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 266 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
266citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
266 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Vasculature segmentation in 3D hierarchical phase-contrast tomography images of human kidneys.Nature communications · 2026Pooled it
- Mechanistic reprogramming of the mtDNA-cGAS-STING axis in cellular senescence: from mitochondrial homeostatic disruption to inflammatory and immune outcomes.Biogerontology · 2026Review
- Cellular senescence: six decades of discovery and reinvention.The EMBO journal · 2026Review
- A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes.Aging cell · 2026Article
- 3D multi-omics tumour atlases: from technology to biology and clinical translation.Nature reviews. Cancer · 2026Review
- uPAR-Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non-Human Primates With Serum Aminotransferase Activity as a Safety Monitor.Aging cell · 2026Article
- The Role of EVs in the Aging Hematopoietic System.Aging cell · 2026Review
- Multiscale harmonization, semantic integration, and immersive exploration of single-cell data in support of novel biological insights.bioRxiv : the preprint server for biology · 2026Article
- Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.Science (New York, N.Y.) · 2026Article
- Vascular aging as a driver of organ dysfunction and systemic aging.Nature cardiovascular research · 2026Review
- Senescent Cell Heterogeneity: Tissue-Dependent Signatures and Age Dynamics Revealed by Human scRNA-Seq Data.International journal of molecular sciences · 2026Article
- Review
- Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology.European heart journal · 2026Review
- Aqueous Extract ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline: Biological Rationale and Current Evidence.Nutrients · 2026Review
- HIF1AJournal for immunotherapy of cancer · 2026Article
- A consensus roadmap from the SENESCENCE2030 network towards precision senescence medicine.Nature aging · 2026Article
- Menopausal timing and senescent-immune coupling in age-related lobular involution of the human breast: a longitudinal cohort study.EBioMedicine · 2026Article
- The Reductive Stress Nexus: Integrated Pathways of Metabolic Dysregulation, Senescence and Blood-Brain Barrier Failure in Neurodegenerative Disease and Brain Aging.Cell biochemistry and biophysics · 2026Review
- Article
206 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
79 authors.
Vidyani SuryadevaraDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4081-2989
Adam D HudginsDepartment of Obstetrics and Gynecology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2737-6839
Adarsh RajeshSanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA.
Alberto PappalardoDepartment of Dermatology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-8949-2552
Alla KarpovaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0467-0215
Amit K DeyNational Institute on Aging, NIH, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3106-7091
Ann HertzelDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Anthony AgudeloDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Azucena RochaDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Bikem SoygurThe Buck Institute for Research on Aging, Novato, CA, USA.
Birgit SchillingThe Buck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-9907-2749
Chase M CarverDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Cristina Aguayo-MazzucatoIslet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0001-5402-1382
Darren J BakerRobert and Arlene Kogod Center on Aging, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9006-1939
David A BernlohrDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Diana JurkDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-4486-0857
Dilyana B MangarovaDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
Ellen M QuardokusDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.
Elizabeth Ann L EnningaDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Elizabeth L SchmidtDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-8111-8382
Feng ChenDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Francesca E DuncanThe Buck Institute for Research on Aging, Novato, CA, USA.
Francesco CambuliNew York Genome Center, New York, NY, USA.
Gagandeep KaurDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
George A KuchelUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.ORCID http://orcid.org/0000-0001-8387-7040
Gung LeeDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Heike E Daldrup-LinkDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
Helene MartiniDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-8789-4585
Hemali PhatnaniNew York Genome Center, New York, NY, USA.
Iman M Al-NaggarUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Irfan RahmanDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Jia NieBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
João F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Jonathan C SilversteinDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-9252-6039
Judith CampisiThe Buck Institute for Research on Aging, Novato, CA, USA.
Julia WangDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Kanako IwasakiIslet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA.ORCID http://orcid.org/0000-0003-1671-3980
Karina BarbosaSanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6233-3332
Kay MetisDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kerem NernekliDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
Laura J NiedernhoferDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Li DingDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Lichao WangUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Lisa C AdamsDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
Liu RuiyangDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Madison L DoolittleDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-0912-0095
Marcos G TenecheSanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4785-7987
Marissa J SchaferDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1470-1583
Ming XuUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-4477-939X
Mohammadjavad HajipourDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.
Mozhgan BoroumandNational Institute on Aging, NIH, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3239-4775
Nathan BasistyNational Institute on Aging, NIH, Baltimore, MD, USA.
Nicholas SloanDepartment of Neurology, Columbia University Medical Center, New York, NY, USA.
Nikolai SlavovCenter on the Biology of Aging, Brown University, Providence, RI, USA.
Olena KuksenkoDepartment of Neurology, Columbia University Medical Center, New York, NY, USA.
Paul RobsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-0191-3958
Paul T GomezDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Periklis VasilikosDepartment of Genetics and Development, Columbia University, New York, NY, USA.ORCID http://orcid.org/0009-0009-8980-338X
Peter D AdamsSanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0684-1770
Priscila CarapetoIslet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA.
Quan ZhuCenter for Epigenomics, University of California, San Diego, CA, USA.
Ramalakshmi RamasamyThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0003-4067-0511
Rolando Perez-LorenzoDepartment of Dermatology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-9355-9617
Rong FanYale-Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-7805-8059
Runze DongDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Ruth R MontgomeryYale-Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8661-4454
Sadiya ShaikhDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Sanja VickovicNew York Genome Center, New York, NY, USA.
Shanshan YinSanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA.
Shoukai KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Sonja SuvakovDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Sundeep KhoslaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-2936-4372
Vesna D GarovicDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Vilas MenonDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Yanxin XuCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yizhe SongDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8760-6432
Yousin SuhDepartment of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
Zhixun DouCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Nicola NerettiDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA. nicola_neretti@brown.edu.ORCID http://orcid.org/0000-0002-9552-1663
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MSPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Albert C Shaw · 2010 to 2026
$50.4MTHE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1MVISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8MTargeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7MCenter for Integrated Cellular Analysis - Valeria A. Sanchez EstradaRM1HG011014 · NHGRI · NEW YORK GENOME CENTER · PI LANDAU, DAN, SATIJA, RAHUL · 2020 to 2025
$22.1MSenNet Supplement - Consortium BenchmarkingU24CA268108 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Philip D. Blood, JONATHAN C. SILVERSTEIN · 2021 to 2026
$22.1MSan Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon, Elena Volpi · 2015 to 2026
$14.1MTriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0MThe KAPP-Sen Tissue Mapping Center CollaborativeU54AG075941 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUCHEL, GEORGE A · 2021 to 2025
$13.8MData Analysis CoreU54AG076040 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHATNANI, HEMALI · 2021 to 2025
$13.1MNCI NIH HHS P30 CA015083NCI NIH HHS U24 CA268108NCI NIH HHS UG3 CA268096NCI NIH HHS UG3 CA268103NCI NIH HHS UG3 CA268105NCI NIH HHS UG3 CA268112NCI NIH HHS UG3 CA268117NCI NIH HHS UG3 CA268202NCI NIH HHS UG3 CA275669NCI NIH HHS UG3 CA275686NCI NIH HHS UH3 CA268103NCI NIH HHS UH3 CA275686NHGRI NIH HHS RM1 HG011014NHLBI NIH HHS R01 HL147290NHLBI NIH HHS R01 HL147575NIAID NIH HHS U19 AI089992NIA NIH HHS F31 AG072748NIA NIH HHS P01 AG017242NIA NIH HHS P01 AG062413NIA NIH HHS P30 AG067988NIA NIH HHS R01 AG050582NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG068182NIA NIH HHS R01 AG069819NIA NIH HHS R01 AG076515NIA NIH HHS R01 AG076642NIA NIH HHS R01 AG082708NIA NIH HHS R33 AG061456NIA NIH HHS T32 AG041688NIA NIH HHS U01 AG060906NIA NIH HHS U54 AG075931NIA NIH HHS U54 AG075932NIA NIH HHS U54 AG075934NIA NIH HHS U54 AG075941NIA NIH HHS U54 AG076040NIA NIH HHS U54 AG076041NIA NIH HHS U54 AG079753NIA NIH HHS U54 AG079754NIA NIH HHS U54 AG079758NIA NIH HHS U54 AG079759NIA NIH HHS U54 AG079779NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK127778NIDDK NIH HHS R01 DK132535NIEHS NIH HHS P30 ES001247NIGMS NIH HHS T32 GM136566NIMH NIH HHS T32 MH126036
Abstract
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest. By contrast, in tissues, these cells are relatively rare and difficult to characterize, and it is now established that fully differentiated, postmitotic cells can also acquire a senescence phenotype. The SenNet Biomarkers Working Group was formed to provide recommendations for the use of cellular senescence markers to identify and characterize senescent cells in tissues. Here, we provide recommendations for detecting senescent cells in different tissues based on a comprehensive analysis of existing literature reporting senescence markers in 14 tissues in mice and humans. We discuss some of the recent advances in detecting and characterizing cellular senescence, including molecular senescence signatures and morphological features, and the use of circulating markers. We aim for this work to be a valuable resource for both seasoned investigators in senescence-related studies and newcomers to the field.
Indexed as
BiomarkersCellular SenescenceAnimalsHumansMiceOrgan SpecificityBiomarkers
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