ArticleNature cancer2024
Tumor-associated macrophages restrict CD8
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Article in Nature cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers.
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204citing papers in PubMed
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Who cites it
204 citing papers in PubMed.
- FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The immunology of human breast cancer.Nature reviews. Immunology · 2026Review
- Targeting the tumor microenvironment: a new strategy for natural products in breast cancer therapy.Natural products and bioprospecting · 2026Review
- DONSON links tumor-cell survival to MIF-associated macrophage remodeling in small cell lung cancer.Apoptosis : an international journal on programmed cell death · 2026Article
- Understanding and targeting the tumour matrisome.Nature reviews. Clinical oncology · 2026Review
- Conserved Metastatic Cell States and Spatial Immune Microenvironment Remodeling Define Pancreatic Cancer Liver Metastases.bioRxiv : the preprint server for biology · 2026Article
- Tumor FAK supports fibrillar collagen expression in ovarian cancer ascites.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- Collagen-Binding IL-15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self-Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lactobacillus salivarius potentiates gastrointestinal cancer immunotherapy through its metabolite chenodeoxycholic acid.Cell reports. Medicine · 2026Article
- Extracellular Matrix Remodeling in Tumors: Forces Beyond Fibroblasts.Cancer research · 2026Article
- Next-generation macrophage engineering in cancer therapy: From TAM reprogramming to CAR-macrophages.Molecular therapy. Nucleic acids · 2026Review
- Spatiotemporally reprogrammed L-arginine metabolic nanoregulator potentiates immunotherapy.Bioactive materials · 2026Article
- LncRNA PCAT7 drives tumorigenesis and glycolytic reprogramming in breast cancer via the ceRNA-mediated miR-204-5p/RUNX2 axis.Cancer gene therapy · 2026Article
- Pyrroline-5-carboxylate reductase 1 interacts with Nudix hydrolase 5 to drive bladder cancer malignant progression via activation of the APOE/JAK2/STAT3 signalling axis.Clinical and translational medicine · 2026Article
- Tissue-Resident Macrophage in Inflammation and Cancer.MedComm · 2026Review
- IGF1-IGF1R signaling in tumor-associated macrophages regulates extracellular matrix organization in BRAF inhibitor-targeted melanoma.Molecular and cellular biochemistry · 2026Article
- Cytokine Regulation of the Bone Pre- and Metastatic Niches: Implications for Breast Cancer Dormancy.Cells · 2026Review
- Article
- Programmable-bacteria-macrophage backpacks for enhanced solid tumor therapy via mechanobiological interplay.Cell reports. Medicine · 2026Article
- Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies.Molecular cancer · 2026Review
144 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors.
Kevin M TharpCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
Kelly KerstenDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7615-2594
Ori MallerCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4149-0179
Greg A TimblinCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9351-3646
Connor StashkoCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
Fernando P CanaleInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Rosa E MenjivarDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Mary-Kate HaywardCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7482-5046
Ilona BerestjukCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
Johanna Ten HoeveUCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Bushra SamadDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2893-0897
Alastrair J IronsideDepartment of Pathology, Western General Hospital, NHS Lothian, Edinburgh, UK.
Marina Pasca di MaglianoDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9632-9035
Alexander MuirBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3811-3054
Roger GeigerInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-8016-1669
Alexis J CombesDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9110-6542
Valerie M WeaverCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA. valerie.weaver@ucsf.edu.ORCID http://orcid.org/0000-0003-4786-6752
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1MMolecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4MTissue mechanics reprograms the tissue to malignancy and metastasisR35CA242447 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALERIE MARIE WEAVER · 2020 to 2026
$6.6MA physical sciences approach to investigate the role of exosomes in metastatic progressionU01CA250044 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GUO, WEI, RADHAKRISHNAN, RAVI · 2021 to 2025
$3.9MReorienting the Glioblastoma Microenvironment to Respond to ImmunotherapyR01NS109911 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARCELLOS-HOFF, MARY HELEN, WEAVER, VALERIE MARIE · 2019 to 2023
$2.9MTension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9MTissue Tension, RANK and Breast Cancer RiskR01CA222508 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HWANG, E.SHELLEY, WEAVER, VALERIE MARIE · 2018 to 2022
$2.8MQuantitative Mass Spectrometer for Targeted and Global Proteomics, MetabolomicsS10OD016387 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRAEBER, THOMAS G · 2013 to 2013
$593kMechanical stress reprograms mitochondrial metabolism to support tumor survival and invasion through the mitochondrial unfolded protein responseF32CA236156 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THARP, KEVIN · 2019 to 2021
$110kNCI NIH HHS F32 CA236156NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA192914NCI NIH HHS R01 CA222508NCI NIH HHS R35 CA242447NCI NIH HHS T32 CA108462NCI NIH HHS U01 CA250044NIH HHS S10 OD016387NINDS NIH HHS R01 NS109911U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1F32CA236156-01A1U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA192914U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA222508-01U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R35 CA242447-01A1
Abstract
Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix accumulation, which is associated with diminished antitumor immune infiltration. Here we demonstrate that tumor-associated macrophages (TAMs) respond to the stiffened fibrotic tumor microenvironment (TME) by initiating a collagen biosynthesis program directed by transforming growth factor-β. A collateral effect of this programming is an untenable metabolic milieu for productive CD8
Indexed as
Breast NeoplasmsCD8-Positive T-LymphocytesCollagenTumor-Associated MacrophagesTumor MicroenvironmentAnimalsFemaleHumansMacrophagesMetabolic ReprogrammingMiceTransforming Growth Factor betaCollagenTransforming Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.