ArticleCommunications chemistry2024
Substrate scope expansion of 4-phenol oxidases by rational enzyme selection and sequence-function relations.
Article in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Robots and Minimal, Physics-Informed Features: A Hybrid Framework for Enzyme Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Discovery of a new subfamily expands the catalytic versatility of vanillyl alcohol oxidases.Frontiers in microbiology · 2026Article
- Regioselective C─H Functionalization by the Combination of Enzymatic and Chemocatalytic Reactions in Water.Angewandte Chemie (International ed. in English) · 2025Article
- Exploration and heterologous expression of laccase genes and pesticide degradation ability of laccases from Cerrena unicolor GC.u01.World journal of microbiology & biotechnology · 2025Article
- Activity assays for flavoprotein oxidases: an overview.Applied microbiology and biotechnology · 2025Review
- Chemoenzymatic synthesis.Communications chemistry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Enzymes are natures' catalysts and will have a lasting impact on (organic) synthesis as they possess unchallenged regio- and stereo selectivity. On the downside, this high selectivity limits enzymes' substrate range and hampers their universal application. Therefore, substrate scope expansion of enzyme families by either modification of known biocatalysts or identification of new members is a key challenge in enzyme-driven catalysis. Here, we present a streamlined approach to rationally select enzymes with proposed functionalities from the ever-increasing amount of available sequence data. In a case study on 4-phenol oxidoreductases, eight enzymes of the oxidase branch were selected from 292 sequences on basis of the properties of first shell residues of the catalytic pocket, guided by the computational tool A
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Registered trials
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