Evidence map›Paper›PMID 38830756›Full record

ArticleeNeuro2024

Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy.

Gwen van der Wijk, Mojdeh Zamyadi, Signe Bray, Stefanie Hassel, Stephen R Arnott, Benicio N Frey, Sidney H Kennedy, Andrew D Davis, Geoffrey B Hall, Raymond W Lam and 7 more

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gwen van der WijkDepartment of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada gwen.vanderwijk@ucalgary.ca.ORCID https://orcid.org/0000-0002-8861-8432
Mojdeh ZamyadiBaycrest Health Sciences, Rotman Research Institute, Toronto, Ontario M6A 2E1, Canada.
Signe BrayChild and Adolescent Imaging Research Program, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Stefanie HasselDepartment of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Stephen R ArnottBaycrest Health Sciences, Rotman Research Institute, Toronto, Ontario M6A 2E1, Canada.
Benicio N FreyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
Sidney H KennedyDepartment of Psychiatry, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Andrew D DavisBaycrest Health Sciences, Rotman Research Institute, Toronto, Ontario M6A 2E1, Canada.
Geoffrey B HallDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1, Canada.ORCID https://orcid.org/0000-0001-7142-4669
Roumen MilevDepartment of Psychiatry and Psychology, and Providence Care Hospital, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Daniel J MüllerDepartment of Psychiatry, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Sagar ParikhDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109.
Claudio SoaresDepartment of Psychiatry, Queen's University, Providence Care, Kingston, Ontario K7L 3N6, Canada.
Glenda M MacqueenDepartment of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Stephen C StrotherBaycrest Health Sciences, Rotman Research Institute, Toronto, Ontario M6A 2E1, Canada.ORCID https://orcid.org/0000-0002-3198-217X
Andrea B ProtznerDepartment of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies of major depression (MD) generally focus on group effects, yet interindividual differences in brain function are increasingly recognized as important and may even impact effect sizes related to group effects. Here, we examine the magnitude of individual differences in relation to group differences that are commonly investigated (e.g., related to MD diagnosis and treatment response). Functional MRI data from 107 participants (63 female, 44 male) were collected at baseline, 2, and 8 weeks during which patients received pharmacotherapy (escitalopram,

Indexed as

Antidepressive AgentsBrainIndividualityMagnetic Resonance ImagingMajor Depressive DisorderAdultCitalopramConnectomeEscitalopramFemaleHumansMaleMiddle AgedYoung AdultAntidepressive AgentsCitalopramEscitalopramfMRIfunctional connectivityindividual differencesmajor depressionpharmacotherapy

Identifiers

PMID38830756
PMCPMC11163402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.