Evidence map›Paper›PMID 38830651›Full record

ArticleSaudi medical journal2024

Real-world treatment patterns and clinical outcomes in patients with prostate cancer.: A single institution experience in Saudi Arabia.

Ruba Abu Khizanah, Emad Tashkandi, Mohammad Jaffal, Mohammed Alsaedi, Yazan Al-Ahmdi, Abdulmajeed Almehmadi, Khaled A Elnaghi

Abstract read
In one paragraph

Article in Saudi medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruba Abu KhizanahFrom the College of Medicine (Abu Khizanah, Tashkandi); from the Facility of Pharmacy (Al-ahmdi, Almehmadi), Umm Al-Qura University, from the Department of Medical Oncology (Tashkandi, Elnaghi), Oncology Centre; from the Department of Pharmacy (Jaffal), King Abdullah Medical City, Makkah, from the Department of Medicine (Alsaedi), Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, and from the Department of Medical Oncology (Elnaghi), Oncology Center, Mansoura University, Mansoura, Egypt.ORCID https://orcid.org/0000-0002-6371-7717
Emad TashkandiFrom the College of Medicine (Abu Khizanah, Tashkandi); from the Facility of Pharmacy (Al-ahmdi, Almehmadi), Umm Al-Qura University, from the Department of Medical Oncology (Tashkandi, Elnaghi), Oncology Centre; from the Department of Pharmacy (Jaffal), King Abdullah Medical City, Makkah, from the Department of Medicine (Alsaedi), Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, and from the Department of Medical Oncology (Elnaghi), Oncology Center, Mansoura University, Mansoura, Egypt.
Mohammad JaffalFrom the College of Medicine (Abu Khizanah, Tashkandi); from the Facility of Pharmacy (Al-ahmdi, Almehmadi), Umm Al-Qura University, from the Department of Medical Oncology (Tashkandi, Elnaghi), Oncology Centre; from the Department of Pharmacy (Jaffal), King Abdullah Medical City, Makkah, from the Department of Medicine (Alsaedi), Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, and from the Department of Medical Oncology (Elnaghi), Oncology Center, Mansoura University, Mansoura, Egypt.
Mohammed AlsaediFrom the College of Medicine (Abu Khizanah, Tashkandi); from the Facility of Pharmacy (Al-ahmdi, Almehmadi), Umm Al-Qura University, from the Department of Medical Oncology (Tashkandi, Elnaghi), Oncology Centre; from the Department of Pharmacy (Jaffal), King Abdullah Medical City, Makkah, from the Department of Medicine (Alsaedi), Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, and from the Department of Medical Oncology (Elnaghi), Oncology Center, Mansoura University, Mansoura, Egypt.
Yazan Al-AhmdiFrom the College of Medicine (Abu Khizanah, Tashkandi); from the Facility of Pharmacy (Al-ahmdi, Almehmadi), Umm Al-Qura University, from the Department of Medical Oncology (Tashkandi, Elnaghi), Oncology Centre; from the Department of Pharmacy (Jaffal), King Abdullah Medical City, Makkah, from the Department of Medicine (Alsaedi), Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, and from the Department of Medical Oncology (Elnaghi), Oncology Center, Mansoura University, Mansoura, Egypt.
Abdulmajeed AlmehmadiFrom the College of Medicine (Abu Khizanah, Tashkandi); from the Facility of Pharmacy (Al-ahmdi, Almehmadi), Umm Al-Qura University, from the Department of Medical Oncology (Tashkandi, Elnaghi), Oncology Centre; from the Department of Pharmacy (Jaffal), King Abdullah Medical City, Makkah, from the Department of Medicine (Alsaedi), Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, and from the Department of Medical Oncology (Elnaghi), Oncology Center, Mansoura University, Mansoura, Egypt.
Khaled A ElnaghiFrom the College of Medicine (Abu Khizanah, Tashkandi); from the Facility of Pharmacy (Al-ahmdi, Almehmadi), Umm Al-Qura University, from the Department of Medical Oncology (Tashkandi, Elnaghi), Oncology Centre; from the Department of Pharmacy (Jaffal), King Abdullah Medical City, Makkah, from the Department of Medicine (Alsaedi), Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia, and from the Department of Medical Oncology (Elnaghi), Oncology Center, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe the current real-world treatment landscape, sequence of therapies, and outcomes in patients with prostate cancer (PC).

methodsA retrospective cohort study for PC patients diagnosed at King Abdullah Medical City Cancer Center in Makkah, Saudi Arabia, between January 2011 and December 2021. Data extracted from electronic medical records.

resultsA total of 282 patients with PC, with a mean age of 70 years and body mass index of 27. Among them, 274 (99%) had no family history of cancer, while 164 (58%) had hypertension and 125 (44%) had diabetes mellitus. Adenocarcinoma was the most common histology, found in 275 (97%) patients, with 99 (35%) having a Gleason score of 9. Notably, 184 (65%) patients presented with metastatic disease, and 147 (52%) with bone metastasis. While 198 (70%) patients underwent surgery, 184 (65%) did not receive radiotherapy. The most common first-line metastatic therapy was abiraterone in 23 (8%) patients, followed by enzalutamide in 7 (2.5%). During the study period, 167 (59%) patients survived, with an average treatment duration of 2.5 years.

conclusionThis study provides insights into real-world treatment patterns and clinical outcomes in patients with PC. The findings of this study highlight the importance of adhering to treatment standards and making informed clinical decisions.

Indexed as

Prostatic NeoplasmsAdenocarcinomaAgedAged, 80 and overAndrostenesBenzamidesBone NeoplasmsCohort StudiesHumansMaleMiddle AgedNeoplasm GradingNitrilesPhenylthiohydantoinProstatectomyRetrospective StudiesabirateroneAndrostenesBenzamidesenzalutamideNitrilesPhenylthiohydantoinnext-generation hormonal agentsobservational studyprostate cancertherapy sequencingtreatment patterns

Identifiers

PMID38830651
PMCPMC11147604

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.