ArticleEnvironmental science & technology2024
The Known and Unknown: Investigating the Carcinogenic Potential of Plastic Additives.
Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Functionalized biochar for plasticizer remediation in aquatic systems: synergistic adsorption and advanced oxidation strategies.RSC advances · 2026Review
- Development of a self-signaling electrochemical sensor utilizing CoNiFe-PBA for detection of Bisphenol A in food samples.Mikrochimica acta · 2026Article
- Inhaled Micro- and Nanoplastics as Environmental Modifiers of Lung Carcinogenesis: Mechanistic Insights and Evidence Synthesis.Journal of xenobiotics · 2026Review
- Microplastics, nanoplastics and liver disease: an emerging health concern?Nature reviews. Gastroenterology & hepatology · 2026Review
- Chemicals in plastics differentially affect the transcriptome of MCF-7 breast cancer cells.Archives of toxicology · 2026Article
- Dietary microplastic exposure and lip-oral cavity cancer: a global ecological analysis with pre-specified spatial econometric sensitivity.Scientific reports · 2026Article
- Microplastics as both a driver of genitourinary cancers and a deliverer of treatments.Communications medicine · 2026Review
- Sea anemones extract tin associated with polyvinyl chloride pre-production pellets.Environmental science. Processes & impacts · 2026Article
- Assessment of different physicochemical parameters of leachates from two locally unbranded yogurt containers in Erbil City, Kurdistan Region, Iraq.Italian journal of food safety · 2026Article
- Per- and Polyfluoroalkyl Substances Leaching from Micro- and Nanoplastics and the Associated Influence of the Plastisphere.Environmental science & technology · 2026Article
- Emerging evidence on micro- and nanoplastics carcinogenicity: mechanisms, models, and signaling networks.Molecular cancer · 2026Review
- Polyethylene terephthalate microplastics impair erectile function through macrophage mediated cGAS-STING ferroptosis.iScience · 2026Article
- Tracking Microplastics From Source to Impact: A Review of Environmental Presence, Exposure, Remediation, and Health Risks.Current environmental health reports · 2026Review
- The carcinogenic consequences of the plastic pollution crisis.The Journal of clinical investigation · 2026Article
- Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF-κB and TGF-β Signaling Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From Kitchen to Cell: A Critical Review of Microplastic Release from Consumer Products and Its Health Implications.Toxics · 2026Review
- Kinetics and Potential Mechanisms of LDPE and PBAT Microplastics Biodeterioration by Soil BacteriaMicroorganisms · 2026Article
- From exposure to oncogenesis: a review on the multifaceted roles of microplastics in tumor initiation and progression.Journal of translational medicine · 2025Review
- Strategies for Designing Circular, Sustainable, and Nonpersistent Consumer Plastic Products: A Case Study of Drinking Straws.Environmental science & technology · 2025Article
- Paint: a ubiquitous yet disregarded piece of the microplastics puzzle.Environmental toxicology and chemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Microplastics are routinely ingested and inhaled by humans and other organisms. Despite the frequency of plastic exposure, little is known about its health consequences. Of particular concern are plastic additives─chemical compounds that are intentionally or unintentionally added to plastics to improve functionality or as residual components of plastic production. Additives are often loosely bound to the plastic polymer and may be released during plastic exposures. To better understand the health effects of plastic additives, we performed a comprehensive literature search to compile a list of 2,712 known plastic additives. Then, we performed an integrated toxicogenomic analysis of these additives, utilizing cancer classifications and carcinogenic expression pathways as a primary focus. Screening these substances across two chemical databases revealed two key observations: (1) over 150 plastic additives have known carcinogenicity and (2) the majority (∼90%) of plastic additives lack data on carcinogenic end points. Analyses of additive usage patterns pinpointed specific polymers, functions, and products in which carcinogenic additives reside. Based on published chemical-gene interactions, both carcinogenic additives and additives with unknown carcinogenicity impacted similar biological pathways. The predominant pathways involved DNA damage, apoptosis, the immune response, viral diseases, and cancer. This study underscores the urgent need for a systematic and comprehensive carcinogenicity assessment of plastic additives and regulatory responses to mitigate the potential health risks of plastic exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.