Evidence map›Paper›PMID 38830472›Full record

Trial reportThe Journal of nutrition2024

Honey Added to Yogurt with Bifidobacterium animalis subsp. lactis DN-173 010/CNCM I-2494 Supports Probiotic Enrichment but Does Not Reduce Intestinal Transit Time in Healthy Adults: A Randomized, Controlled, Crossover Trial.

Annemarie R Mysonhimer, Marina D Brown, David A Alvarado, Eva Cornman, Myra Esmail, Tehila Abdiel, Karen Gutierrez, Jorge Vasquez, Corinne N Cannavale, Michael J Miller and 2 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04187950 nacompletednot on this map

NECTAR Study: Nectar (Honey) Effects on Comfort, Thoughts, and Regularity

TypeinterventionalSponsorUniversity of Illinois at Urbana-ChampaignRan2021 to 2022Enrolled66ConditionsGastrointestinal Dysfunction, Physiological Stress, Cognition - OtherArmsYogurt with B. lactis and added honey, Yogurt with heat-inactivated B. lactis and added cane sugar
NCT04901390 nacompletednot on this map

Impact of Yogurt on Gastrointestinal Health, Regularity, and Thoughts

TypeinterventionalSponsorUniversity of Illinois at Urbana-ChampaignRan2021 to 2022Enrolled66ConditionsGastrointestinal Dysfunction, Physiological Stress, Cognition - OtherArmsYogurt with B. lactis and added cane sugar
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Microbiome: A Key Regulator of Body-Brain Interactions.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Annemarie R MysonhimerDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Marina D BrownDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States.
David A AlvaradoDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Eva CornmanDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Myra EsmailDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Tehila AbdielDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Karen GutierrezDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Jorge VasquezDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Corinne N CannavaleDepartment of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Michael J MillerDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Naiman A KhanDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States; Department of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL, United States; Neuroscience Program, University of Illinois, Urbana, IL, United States.
Hannah D HolscherDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, United States; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. Electronic address: hholsche@illinois.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHoney improves probiotic survival in vitro. However, if this effect translates to humans has not been investigated.

objectivesWe aimed to determine effects of honey plus yogurt containing the probiotic Bifidobacterium animalis subsp. lactis DN-173 010/CNCM I-2494 (B. animalis) on intestinal transit time, probiotic enrichment, digestive health, mood, and cognition in adults.

methodsSixty-six healthy adults (34 female; 33.6 ± 9.8 y; 24.6 ± 3.0 kg/m

resultsB. animalis was enriched in HON (d = 3.54; P = 0.0002) compared to controls with linear discriminant analysis effect size. Intestinal transit time, gastrointestinal health, mood, and cognition did not differ between conditions (LMM: Ps > 0.05).

conclusionsYogurt + honey enriched B. animalis but did not reduce intestinal transit time or have other functional gastrointestinal, mood, or cognitive effects in adults. This trial was registered at www. CLINICALTRIALS: gov as NCT04187950 and NCT04901390.

Indexed as

Bifidobacterium animalisCross-Over StudiesGastrointestinal TransitHoneyProbioticsYogurtAdultAffectCognitionFemaleHumansMaleYoung Adultanxietycognitiondepressionmoodregularitystress

Identifiers

PMID38830472
PMCPMC11375456

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.