Evidence map›Paper›PMID 38830096›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Epitranscriptomic cytidine methylation of the hepatitis B viral RNA is essential for viral reverse transcription and particle production.

Pei-Yi Alma Su, Chih-Hsu Chang, Shin-Chwen Bruce Yen, Hsiu-Yi Wu, Wan-Ju Tung, Yu-Pei Hu, Yen-Yu Ian Chen, Miao-Hsia Lin, Chiaho Shih, Pei-Jer Chen and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. RNA modification is the mark and strategy for host-microbe interactions.Cellular and molecular life sciences : CMLS · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pei-Yi Alma SuInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0002-6354-2152
Chih-Hsu ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-2639-9649
Shin-Chwen Bruce YenInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-1200-3922
Hsiu-Yi WuInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Wan-Ju TungInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-1122-2023
Yu-Pei HuInstitute of Biomedical Sciences Summer Undergraduate Internship Program, Academia Sinica, Taipei 115, Taiwan.
Yen-Yu Ian ChenInstitute of Biomedical Sciences Summer Undergraduate Internship Program, Academia Sinica, Taipei 115, Taiwan.
Miao-Hsia LinDepartment of Microbiology, National Taiwan University College of Medicine, Taipei 100, Taiwan.ORCID 0000-0002-7079-4569
Chiaho ShihGraduate Institute of Cell Biology, College of Life Sciences, China Medical University, Taichung 404, Taiwan.
Pei-Jer ChenNational Taiwan University Center for Genomic Medicine, National Taiwan University, Taipei 100, Taiwan.
Kevin TsaiInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-1712-9153

Funding

Center for Structural Biology of HIV RNAU54AI170660 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALICE TELESNITSKY · 2022 to 2026
$32.1M
Academia Sinica (AS) AS-CDA-112-L02National Science and Technology Council (NSTC) 112-2320-B-001-023National Science and Technology Council (NSTC) 112-2320-B-039-061National Science and Technology Council (NSTC) 112-2326-B-002-001NIAID NIH HHS U54 AI170660
6 · The paper itself

Abstract

Epitranscriptomic RNA modifications have emerged as important regulators of the fate and function of viral RNAs. One prominent modification, the cytidine methylation 5-methylcytidine (m

Indexed as

CytidineHepatitis B virusReverse TranscriptionRNA, ViralEpigenesis, GeneticHumansMethylationTranscriptomeVirionVirus Replication5-methylcytidineCytidineRNA, Viralhepatitis B virusm5CNSUN2reverse transcriptionRNA modifications

Identifiers

PMID38830096
PMCPMC11181118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.