ArticleSleep2024
Associations between longitudinal changes in sleep stages and risk of cognitive decline in older men.
Article in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- EEG Brain Rhythms During Resting-State Wakefulness and Sleep in Elderly Expert Meditators.Journal of sleep research · 2026Article
- Associations Between Obstructive Sleep Apnea, Macro-Scale Glymphatic Coupling, and Episodic Memory Impairment in Middle-Aged and Older Adults.Nature and science of sleep · 2026Article
- Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women.Neurology · 2025Article
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9 authors.
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Abstract
STUDY
objectivesTo investigate the relationships between longitudinal changes in sleep stages and the risk of cognitive decline in older men.
methodsThis study included 978 community-dwelling older men who participated in the first (2003-2005) and second (2009-2012) sleep ancillary study visits of the Osteoporotic Fractures in Men Study. We examined the longitudinal changes in sleep stages at the initial and follow-up visits, and the association with concurrent clinically relevant cognitive decline during the 6.5-year follow-up.
resultsMen with low to moderate (quartile 2, Q2) and moderate increase (Q3) in N1 sleep percentage had a reduced risk of cognitive decline on the modified mini-mental state examination compared to those with a substantial increase (Q4) in N1 sleep percentage. Additionally, men who experienced a low to moderate (Q2) increase in N1 sleep percentage had a lower risk of cognitive decline on the Trails B compared with men in the reference group (Q4). Furthermore, men with the most pronounced reduction (Q1) in N2 sleep percentage had a significantly higher risk of cognitive decline on the Trails B compared to those in the reference group (Q4). No significant association was found between changes in N3 and rapid eye movement sleep and the risk of cognitive decline.
conclusionsOur results suggested that a relatively lower increase in N1 sleep showed a reduced risk of cognitive decline. However, a pronounced decrease in N2 sleep was associated with concurrent cognitive decline. These findings may help identify older men at risk of clinically relevant cognitive decline.
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