ArticleAngewandte Chemie (International ed. in English)2024
In vivo Metabolic Sensing of Hyperpolarized [1-
Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Nonresonant SABRE provides an additional versatile hyperpolarization approach in magnetic resonance.Science advances · 2026Article
- IrTMes - a stable SABRE catalyst for the hyperpolarization of [1-The Analyst · 2026Article
- Minute-Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen-Based Hyperpolarization.Angewandte Chemie (International ed. in English) · 2026Article
- High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Hyperpolarization of [1-Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From Unlocking Pyruvate Hyperpolarization by Signal Amplification by Reversible Exchange (SABRE) to Clinical Prospects.ACS omega · 2026Review
- Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025Article
- SABRE Ir-IMes Catalysis for the Masses.Molecules (Basel, Switzerland) · 2025Article
- Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025Article
- High HThe journal of physical chemistry letters · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Real-time visualization of metabolic processes in vivo provides crucial insights into conditions like cancer and metabolic disorders. Metabolic magnetic resonance imaging (MRI), by amplifying the signal of pyruvate molecules through hyperpolarization, enables non-invasive monitoring of metabolic fluxes, aiding in understanding disease progression and treatment response. Signal Amplification By Reversible Exchange (SABRE) presents a simpler, cost-effective alternative to dissolution dynamic nuclear polarization, eliminating the need for expensive equipment and complex procedures. We present the first in vivo demonstration of metabolic sensing in a human pancreatic cancer xenograft model compared to healthy mice. A novel perfluorinated Iridium SABRE catalyst in a fluorinated solvent and methanol blend facilitated this breakthrough with a 1.2-fold increase in [1-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.