Evidence map›Paper›PMID 38829504›Full record

ArticleInflammopharmacology2024

Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice.

Lurong Miao, Ziqi Yuan, Shijia Zhang, Guangqin Zhang

Abstract read
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Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lurong MiaoDepartment of Clinical Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China.
Ziqi YuanDepartment of Clinical Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China.
Shijia ZhangSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Guangqin ZhangDepartment of Clinical Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China. njzhanggq@163.com.ORCID http://orcid.org/0000-0002-0282-3807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether honokiol (HNK) acted as an analgesic in connection with inhibiting the voltage-gated proton channel (Hv1).

methodsThe model of gouty arthritis was induced by injecting monosodium urate (MSU) crystals into the hind ankle joint of mice. HNK was given by intragastric administration. Ankle swelling degree and mechanical allodynia were evaluated using ankle joint circumference measurement and von Frey filaments, respectively. Hv1 current, tail current, and action potential in dorsal root ganglion (DRG) neurons were recorded with patch-clamp techniques.

resultsHNK (10, 20, 40 mg/kg) alleviated inflammatory response and mechanical allodynia in a dose-dependent manner. In normal DRG neurons, 50 µM Zn

conclusionHNK may be a potential analgesic by inhibiting Hv1 current.

Indexed as

Arthritis, GoutyBiphenyl CompoundsGanglia, SpinalIon ChannelsLignansUric AcidAction PotentialsAllyl CompoundsAnalgesicsAnimalsDisease Models, AnimalDose-Response Relationship, DrugHyperalgesiaMaleMiceNeuronsAllyl CompoundsAnalgesicsBiphenyl CompoundshonokiolHv1 proton channel, mouseIon ChannelsLignansPhenolsUric AcidDRG neuronsGouty arthritisHonokiolVoltage-gated proton channels

Identifiers

PMID38829504

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.