Evidence map›Paper›PMID 38829453›Full record

ArticleThe European physical journal. E, Soft matter2024

A microfluidic platform for the synthesis of polymer and polymer-protein-based protocells.

Jessica Ann O'Callaghan, Neha P Kamat, Kevin B Vargo, Rajarshi Chattaraj, Daeyeon Lee, Daniel A Hammer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European physical journal. E, Soft matter, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica Ann O'CallaghanDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA, 19104, USA.
Neha P KamatDepartment of Biongineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA, 19104, USA.
Kevin B VargoDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA, 19104, USA.
Rajarshi ChattarajDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA, 19104, USA.
Daeyeon LeeDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA, 19104, USA. daeyeon@seas.upenn.edu.
Daniel A HammerDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA, 19104, USA. hammer@seas.upenn.edu.ORCID http://orcid.org/0000-0002-3522-3154

Funding

Functionalized lipid inactosomes to bind and clear SARS-CoV-2R21AI169498 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAMMER, DANIEL A · 2022 to 2023
$444k
Department of the Energy DE-SC0007063NIAID NIH HHS R21 AI169498NIH HHS R21AI169498
6 · The paper itself

Abstract

In this study, we demonstrate the fabrication of polymersomes, protein-blended polymersomes, and polymeric microcapsules using droplet microfluidics. Polymersomes with uniform, single bilayers and controlled diameters are assembled from water-in-oil-in-water double-emulsion droplets. This technique relies on adjusting the interfacial energies of the droplet to completely separate the polymer-stabilized inner core from the oil shell. Protein-blended polymersomes are prepared by dissolving protein in the inner and outer phases of polymer-stabilized droplets. Cell-sized polymeric microcapsules are assembled by size reduction in the inner core through osmosis followed by evaporation of the middle phase. All methods are developed and validated using the same glass-capillary microfluidic apparatus. This integrative approach not only demonstrates the versatility of our setup, but also holds significant promise for standardizing and customizing the production of polymer-based artificial cells.

Indexed as

Artificial CellsPolymersCapsulesEmulsionsMicrofluidic Analytical TechniquesMicrofluidicsProteinsWaterCapsulesEmulsionsPolymersProteinsWater

Identifiers

PMID38829453
PMCPMC11147907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.