ArticleNano letters2024
From Bulk to Single Molecules: Surface-Enhanced Raman Scattering of Cytochrome C Using Plasmonic DNA Origami Nanoantennas.
Article in Nano letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- DNA Origami and Their Application in Biosensors.Biosensors · 2026Review
- DNA origami-engineered gold nanoparticle multimers for ultrasensitive, label-free SERS detection of small molecules and biomolecules.RSC advances · 2026Article
- DNA Nanostructure-Assembled Metallic Nanoparticles for Biosensing Applications.Molecules (Basel, Switzerland) · 2026Review
- Supramolecular Stabilization of Single-Molecule SERS: Cucurbit[7]uril Encapsulation of Thionine.ACS physical chemistry Au · 2026Article
- DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Article
- Raman Monitoring ofInternational journal of molecular sciences · 2025Article
- Watching a Single Enzyme at Work Using Single-Molecule Surface-Enhanced Raman Scattering and DNA Origami-Based Plasmonic Antennas.ACS nano · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome C, an evolutionarily conserved protein, plays pivotal roles in cellular respiration and apoptosis. Understanding its molecular intricacies is essential for both academic inquiry and potential biomedical applications. This study introduces an advanced single-molecule surface-enhanced Raman scattering (SM-SERS) system based on DNA origami nanoantennas (DONAs), optimized to provide unparalleled insights into protein structure and interactions. Our system effectively detects shifts in the Amide III band, thereby elucidating protein dynamics and conformational changes. Additionally, the system permits concurrent observations of oxidation processes and Amide bands, offering an integrated view of protein structural and chemical modifications. Notably, our approach diverges from traditional SM-SERS techniques by de-emphasizing resonance conditions for SERS excitation, aiming to mitigate challenges like peak oversaturation. Our findings underscore the capability of our DONAs to illuminate single-molecule behaviors, even within aggregate systems, providing clarity on molecular interactions and behaviors.
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Registered trials
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