ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Mechanochemistry Drives Alkene Difunctionalization via Radical Ligand Transfer and Electron Catalysis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Navigating Nitration Chemistry: A Practical Guide to Reagents, Mechanisms, and Selectivity.Angewandte Chemie (International ed. in English) · 2026Review
- Chloroalkylation of Unactivated Alkenes via a Cobalt-Mediated Radical Ligand Transfer (RLT) Photoredox Catalysis Platform.JACS Au · 2025Article
- Bimolecular Homolytic Substitution (SACS central science · 2025Review
- Review
- Mechanochemical nitration of arenes and alcohols using a bench-stable organic nitrating reagent.Green chemistry : an international journal and green chemistry resource : GC · 2025Article
- Consecutive mechanical-force-induced electron transfer for reduction of aryl halides with high reduction potentials.Nature communications · 2025Article
- Mechanochemical Sequential Deoxygenative Cross-Coupling Reactions of Phenols Under Ruthenium-Nickel Catalysis.Molecules (Basel, Switzerland) · 2025Article
- Photoredox radical/polar crossover enables carbo-heterofunctionalization of alkenes: facile access to 1,3-difunctionalized nitro compounds.Chemical communications (Cambridge, England) · 2025Article
- Mechanochemistry Drives Alkene Difunctionalization via Radical Ligand Transfer and Electron Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A general and modular protocol is reported for olefin difunctionalization through mechanochemistry, facilitated by cooperative radical ligand transfer (RLT) and electron catalysis. Utilizing mechanochemical force and catalytic amounts of 2,2,6,6-tetramethylpiperidinyloxyl (TEMPO), ferric nitrate can leverage nitryl radicals, transfer nitrooxy-functional group via RLT, and mediate an electron catalysis cycle under room temperature. A diverse range of activated and unactivated alkenes exhibited chemo- and regioselective 1,2-nitronitrooxylation under solvent-free or solvent-less conditions, showcasing excellent functional group tolerance. Mechanistic studies indicated a significant impact of mechanochemistry and highlighted the radical nature of this nitrative difunctionalization process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.