Evidence map›Paper›PMID 38829139›Full record

ArticleJournal of virology2024

Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques.

Archana Vidya Boopathy, Anurag Nekkalapudi, Janette Sung, Sophie Schulha, Debi Jin, Bhawna Sharma, Sarah Ng, Sabrina Lu, Raphaela Wimmer, Silpa Suthram and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Archana Vidya BoopathyClinical Virology, Gilead Sciences, Inc., Foster, California, USA.ORCID 0009-0009-9164-0858
Anurag NekkalapudiClinical Virology, Gilead Sciences, Inc., Foster, California, USA.
Janette SungDrug Metabolism, Gilead Sciences, Inc., Foster, California, USA.
Sophie SchulhaVirology, Hookipa Pharma Inc., New York, New York, USA.
Debi JinProtein Therapeutics, Gilead Sciences, Inc., Foster, California, USA.
Bhawna SharmaDiscovery Virology, Gilead Sciences, Inc., Foster, California, USA.
Sarah NgOncology, Gilead Sciences, Inc., Foster, California, USA.
Sabrina LuProtein Therapeutics, Gilead Sciences, Inc., Foster, California, USA.
Raphaela WimmerVirology, Hookipa Pharma Inc., New York, New York, USA.
Silpa SuthramBioinformatics, Gilead Sciences, Inc., Foster, California, USA.
Sarah Ahmadi-ErberVirology, Hookipa Pharma Inc., New York, New York, USA.
Henning LauterbachGlobal Research and Development, Hookipa Pharma Inc., New York, New York, USA.
Klaus K OrlingerGlobal Research and Development, Hookipa Pharma Inc., New York, New York, USA.
Magdeleine HungProtein Therapeutics, Gilead Sciences, Inc., Foster, California, USA.
Brian CarrDrug Metabolism, Gilead Sciences, Inc., Foster, California, USA.
Christian CallebautClinical Virology, Gilead Sciences, Inc., Foster, California, USA.
Romas GeleziunasClinical Virology, Gilead Sciences, Inc., Foster, California, USA.
Michelle KuhneOncology, Gilead Sciences, Inc., Foster, California, USA.
Sarah SchmidtVirology, Hookipa Pharma Inc., New York, New York, USA.
Brie FalkardClinical Virology, Gilead Sciences, Inc., Foster, California, USA.ORCID 0009-0006-8599-8173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arenaviral vaccine vectors encoding simian immunodeficiency virus (SIV) immunogens are capable of inducing efficacious humoral and cellular immune responses in nonhuman primates. Several studies have evaluated the use of immune modulators to further enhance vaccine-induced T-cell responses. The hematopoietic growth factor Flt3L drives the expansion of various bone marrow progenitor populations, and administration of Flt3L was shown to promote expansion of dendritic cell populations in spleen and blood, which are targets of arenaviral vectors. Therefore, we evaluated the potential of Flt3 signaling to enhance the immunogenicity of arenaviral vaccines encoding SIV immunogens (SIV

Indexed as

Dendritic CellsMacaca mulattaSAIDS VaccinesSimian Immunodeficiency VirusAnimalsAntibodies, ViralCD8-Positive T-Lymphocytesfms-Like Tyrosine Kinase 3Genetic VectorsImmunogenicity, VaccineMembrane ProteinsSimian Acquired Immunodeficiency SyndromeAntibodies, Viralflt3 ligand proteinfms-Like Tyrosine Kinase 3Membrane ProteinsSAIDS Vaccinesarenavirus vectorsFlt3 agonismHIV/SIV vaccineimmunogenicity

Identifiers

PMID38829139
PMCPMC11265421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.