Evidence map›Paper›PMID 38829049›Full record

ArticleAntimicrobial agents and chemotherapy2024

Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets.

Samuel L M Raines, Shane D Falcinelli, Jackson J Peterson, Ellen Van Gulck, Brigitte Allard, Jennifer Kirchherr, Jerel Vega, Isabel Najera, Daniel Boden, Nancie M Archin and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Samuel L M Raines *Department of Medicine and UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Shane D Falcinelli *Department of Medicine and UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jackson J PetersonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ellen Van GulckJanssen Infectious Diseases, Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium.ORCID 0009-0008-3343-0644
Brigitte AllardDepartment of Medicine and UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jennifer KirchherrDepartment of Medicine and UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jerel VegaArcturus Therapeutics, Science Center Drive, San Diego, California, USA.
Isabel NajeraJanssen Infectious Diseases, Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Daniel BodenJanssen Infectious Diseases, Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Nancie M ArchinDepartment of Medicine and UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-7938-0389
David M MargolisDepartment of Medicine and UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-5714-0002

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Project 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$35.7M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI164567 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2021 to 2026
$31.6M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U54-AI170792HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) UM1-AI164567NIAID NIH HHS P30 AI050410NIAID NIH HHS U54 AI170792NIAID NIH HHS UM1 AI164567
6 · The paper itself

Abstract

Limited cellular levels of the HIV transcriptional activator Tat are one contributor to proviral latency that might be targeted in HIV cure strategies. We recently demonstrated that lipid nanoparticles containing HIV

Indexed as

Histone Deacetylase InhibitorsHIV-1HIV InfectionsNanoparticlestat Gene Products, Human Immunodeficiency VirusVirus LatencyAnti-HIV AgentsCD4-Positive T-LymphocytesHIV AntigensHumansRNA, MessengerAnti-HIV AgentsHistone Deacetylase InhibitorsHIV AntigensRNA, Messengertat Gene Products, Human Immunodeficiency VirusHIVlatencylipidnanoparticlesreversalTat

Identifiers

PMID38829049
PMCPMC11232404

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.