Evidence map›Paper›PMID 38829020›Full record

ArticleACS chemical biology2024

Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers.

Panayotis C Theodoropoulos, Holly H Guo, Wentian Wang, Eric Crossley, Giomar Rivera Cancel, Min Fang, Thu Nguyen, Hamid Baniasadi, Noelle S Williams, Joseph M Ready and 2 more

Erratum issuedAbstract read
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Panayotis C TheodoropoulosDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Holly H GuoDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Wentian WangDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Eric CrossleyDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Giomar Rivera CancelDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Min FangDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Thu NguyenDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Hamid BaniasadiDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Noelle S WilliamsDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Joseph M ReadyDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.ORCID 0000-0003-1305-9581
Jef K De BrabanderDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.ORCID 0000-0001-8816-5798
Deepak NijhawanDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.ORCID 0000-0001-6253-4268

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and RegenerationRM1GM142002 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MARKOWITZ, SANFORD D., PIEPER, ANDREW A · 2021 to 2025
$6.9M
NCI NIH HHS P30 CA142543NIDDK NIH HHS P30 DK127984NIGMS NIH HHS RM1 GM142002
6 · The paper itself

Abstract

N-Pyridinylthiophene carboxamide (compound 21) displays activity against peripheral nerve sheath cancer cells and mouse xenografts by an unknown mechanism. Through medicinal chemistry, we identified a more active derivative, compound

Indexed as

NADNiacinamideThiophenesAnimalsAntineoplastic AgentsCell Line, TumorEnzyme InhibitorsHumansIMP DehydrogenaseMiceNerve Sheath NeoplasmsNicotinamide-Nucleotide AdenylyltransferaseNicotinamide PhosphoribosyltransferaseAntineoplastic AgentsEnzyme InhibitorsIMP DehydrogenaseNADNiacinamideNicotinamide-Nucleotide AdenylyltransferaseNicotinamide PhosphoribosyltransferaseThiophenes

Identifiers

PMID38829020
PMCPMC12300662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.