Evidence map›Paper›PMID 38828868›Full record

ArticleMolecular pain

Morphine acts in vitro to directly prime nociceptors.

Eugen V Khomula, Jon D Levine

Abstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eugen V KhomulaDepartment of Oral & Maxillofacial Surgery, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0221-2237
Jon D LevineDepartment of Oral & Maxillofacial Surgery, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0681-5545

Funding

Chronic Chemotherapy Peripheral Neuropathy: Role of Neuroplasticity and StressR01CA250017 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2019 to 2023
$3.3M
Hyaluronan signaling to nociceptors in inflammatory painR01AR075334 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2019 to 2023
$3.0M
NCI NIH HHS R01 CA250017NIAMS NIH HHS R01 AR075334
6 · The paper itself

Abstract

Hyperalgesic priming is a preclinical model of the transition from acute to chronic pain characterized by a leftward shift in the dose-response curve for and marked prolongation of prostaglandin E

Indexed as

DinoprostoneMorphineNociceptorsAnalgesics, OpioidAnimalsDose-Response Relationship, DrugGanglia, SpinalHyperalgesiaMaleRatsRats, Sprague-DawleyReceptors, Opioid, muAnalgesics, OpioidDinoprostoneMorphineReceptors, Opioid, muMorphinenociceptoropioid-induced hyperalgesic primingpatch-clamp electrophysiologyprostaglandin E2rheobasesensitization

Identifiers

PMID38828868
PMCPMC11149440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.