Evidence map›Paper›PMID 38828685›Full record

ArticleBJPsych open2024

Involvement of propranolol in suicides: cross-sectional study using coroner-reported data.

Hayley C Gorton, Charlotte Archer, Thikra Algahtani, Faraz Mughal, Caroline S Copeland

Abstract read
In one paragraph

Article in BJPsych open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The problem of propranolol poisoning.British journal of clinical pharmacology · 2025
    Article
  4. BJPsych open · 2025
    Review
  5. Propranolol in anxiety: poor evidence for efficacy and toxicity in overdose.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hayley C GortonAston Pharmacy School, Aston University, UK; and School of Applied Sciences, University of Huddersfield, UK.ORCID https://orcid.org/0000-0001-5017-9174
Charlotte ArcherBristol Medical School, University of Bristol, UK.ORCID https://orcid.org/0000-0003-4762-2950
Thikra AlgahtaniCentre for Pharmaceutical Medicine Research, Institute of Pharmaceutical Science, King's College London, UK; and National Programme on Substance Use Mortality, London, UK.
Faraz MughalSchool of Medicine, Keele University, UK.ORCID https://orcid.org/0000-0002-5437-5962
Caroline S CopelandCentre for Pharmaceutical Medicine Research, Institute of Pharmaceutical Science, King's College London, UK; and National Programme on Substance Use Mortality, London, UK.ORCID https://orcid.org/0000-0002-4462-1402

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPropranolol is a beta-blocker medication indicated mostly for heart rhythm conditions and for physical symptoms of anxiety. Prescriptions for propranolol in the UK have increased since 2008. Recently, there have been concerns about the involvement of propranolol in intentional poisonings, but such deaths are not routinely reported. Therefore, use of coroner-reported and toxicology data enables unique investigation into the scale of involvement of propranolol in suicide.

aimsTo describe the extent to which propranolol is involved in suicides, including patterns over time and characteristics of people whose suicide involved propranolol compared with other suicides.

methodData were derived from the National Programme on Substance Use Mortality (NPSUM). All suicides and deaths of undetermined intent between 2010 and 2021 in England, Wales and Northern Ireland were extracted, and a subset was identified where propranolol was involved in death.

resultsThere were 4473 suicides of which 297 (6.6%) involved propranolol, with the proportion involving propranolol nearly quadrupling during the study period (3.4%

conclusionsA small number, but increasing proportion, of suicides reported to the NPSUM involve propranolol. Vigilance to the combined toxicity profile of medicines used alongside propranolol may be pertinent.

Indexed as

antidepressantsepidemiologyprimary carepropranololSuicide

Identifiers

PMID38828685
PMCPMC11363079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.