ArticleSultan Qaboos University medical journal2024
Managing the Adverse Events Associated with Pembrolizumab and Lenvatinib Therapy in Endometrial Cancer.
Article in Sultan Qaboos University medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A multicenter, international, randomized, single-blind, placebo-controlled study of the efficacy and safety of inosine-nicotinamide-riboflavin-succinic acid in the acute period of traumatic brain injury in adults.Frontiers in neurology · 2025Trial
- Towards a Latin American neuropsychiatry: challenges and opportunities.Lancet regional health. Americas · 2026Review
- Case report: Effective treatment of posttraumatic aggression in a child affected by TBI treated with long-acting injectable paliperidone: a case study and literature review.Frontiers in psychiatry · 2026Article
- Tractography-Based Asymmetries in Acquired Brain Injury: Contributions to the Neuropsychological Profile and Rehabilitation in a Case-Series.Brain sciences · 2025Article
- Generative Artificial Intelligence in Academic Publishing:Sultan Qaboos University medical journal · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
Endometrial cancer (EC) is the most common gynaecological cancer. The combination of lenvatinib and pembrolizumab has exhibited efficacy as the second line treatment for advanced EC, with a significant benefit in terms of progression free survival (PFS) and overall survival, but the adverse events (AE) profile is complex. AEs associated with the treatment may represent a limitation to this combination. Here, we report the case of a 38-year-old female patient diagnosed with stage IV EC elsewhere, whose disease progressed after the first line of treatment and was referred to a specialised cacncer centre in Muscat, Oman, in 2021. We treated her with the combination of lenvatinib and pembrolizumab. During the course of the treatment, she developed hand-foot syndrome grade III and hypothyroidism grade II. The AEs were managed with supportive medications, dose interruptions, dose reductions and multidisciplinary care, which allowed the continuation of the treatment. The patient achieved a good partial response and an ongoing PFS of more than 12 months.
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Registered trials
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