ArticleMalariaWorld journal2013
Intermittent preventive treatment with sulfadoxine-pyrimethamine versus weekly chloroquine prophylaxis for malaria in pregnancy in Honiara, Solomon Islands: a randomised trial.
Article in MalariaWorld journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00964691 (Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine Versus Weekly Chloroquine Prophylaxis During Pregnancy in Solomon Islands), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine Versus Weekly Chloroquine Prophylaxis During Pregnancy in Solomon Islands: a Randomized Controlled Trial
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of statistical methods for safety data in malaria chemoprevention in pregnancy trials.Malaria journal · 2020Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Solomon Islands is a malarious nation in the Pacific with all four human Methods: We conducted a parallel-group, open label, individually randomised superiority trial comparing weekly chloroquine prophylaxis (CQ) with intermittent preventive treatment (IPTp) with sulfadoxine-pyrimethamine (SP) between August 2009- June 2010 among pregnant women aged 15 to 49 years. Participants were randomised at the first antenatal visit using a computer-generated sequence and followed until delivery. Data on mosquito avoidance measures, and pregnancy outcomes were collected. Results: Because of the low prevalence of malaria, enrolment was prematurely terminated. Among 660 participants (336 in CQ arm, and 324 in IPTp), 68% used a bednet, 53% used window-screens, and 26% lived in a house sprayed in the last 6 months; 91% used at least one of these methods. Peripheral parasitemia at enrolment was 1.5%. At delivery there were no differences between weekly CQ and IPTp in placental parasitemia (0/259 vs. 1/254) or peripheral parasitemia (2/281 vs. 1/267). There were no differences in maternal anaemia, birth outcomes or serious adverse events. A self-reported sulfa-allergy required non-inclusion for 199 of 771 ineligible women (26%). Conclusions: The use of SP for IPTp is not suitable for prevention of malaria in pregnancy in Solomon Islands, given the low malaria prevalence and the possible high prevalence of sulfa-allergy. Scaling up of transmission-reducing interventions has probably contributed to the malaria reduction in Honiara. Trial registration: NCT00964691 ClinicalTrials.gov.
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