Evidence map›Paper›PMID 38827742›Full record

ArticleFrontiers in immunology2024

OTULIN haploinsufficiency predisposes to environmentally directed inflammation.

Frederik Staels, Leoni Bücken, Leana De Vuyst, Mathijs Willemsen, Erika Van Nieuwenhove, Margaux Gerbaux, Julika Neumann, Vanshika Malviya, Lize Van Meerbeeck, Jeason Haughton and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Monogenic disorders of the TNF signalling pathway.Nature reviews. Rheumatology · 2026
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Frederik Staels *Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Leoni Bücken *Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Leana De Vuyst *Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Mathijs WillemsenDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Erika Van NieuwenhoveDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Margaux GerbauxDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Julika NeumannDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Vanshika MalviyaDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Lize Van MeerbeeckDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Jeason HaughtonDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Laura SeldeslachtsDepartment of Imaging and Pathology, Biomedical MRI, KU Leuven, Leuven, Belgium.
Mieke GouwyDepartment of Microbiology, Immunology and Transplantation, Molecular Immunology, KU Leuven, Leuven, Belgium.
Kimberly MartinodDepartment of Microbiology, Immunology and Transplantation, Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.
Greetje Vande VeldeDepartment of Imaging and Pathology, Biomedical MRI, KU Leuven, Leuven, Belgium.
Paul ProostDepartment of Microbiology, Immunology and Transplantation, Molecular Immunology, KU Leuven, Leuven, Belgium.
Lidia YshiiDepartment of Neuroscience, KU Leuven, Leuven, Belgium.
Susan SchlennerDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Rik SchrijversDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Adrian ListonDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Stephanie Humblet-BaronDepartment of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, OTULIN haploinsufficiency was linked to enhanced susceptibility to

Indexed as

HaploinsufficiencyInflammationLipopolysaccharidesMacrophagesAnimalsCytokinesDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutPoly I-CCytokinesLipopolysaccharidesPoly I-Cinborn errors in immunityinflammationOTULINOTULIN deficiencyOTULIN-related autoinflammatory syndrome

Identifiers

PMID38827742
PMCPMC11140568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.